Everyday cognition scales are related to cognitive function in the early stage of probable Alzheimer's disease and FDG-PET findings

Jung Lung Hsu, Wen Chuin Hsu, Chiung Chih Chang, Kun Ju Lin, Ing Tsung Hsiao, Yen Chun Fan*, Chyi Huey Bai

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

18 Scopus citations

Abstract

We applied the Everyday Cognition (ECog) scale in normal aging adults and patients with Alzheimer's disease (AD) to investigate associations between neuropsychological tests and neuroimaging markers. A total of 160 normal aging adults and 40 patients with the early stage of probable AD were included. Neuropsychological performance was assessed using the Consortium to Establish a Registry for Alzheimer's Disease Neuropsychological Assessment Battery (CERAD-NAB). 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) scans were used to measure AD-related hypometabolism. Nonparametric Spearman correlation analysis was used to study associations between ECog and z-transformed total CERAD-NAB scores in both groups. The results revealed a significant correlation between total ECog and CERAD-NAB scores (rho = -0.28, p < 0.01), and category verbal fluency test with the executive domain of the ECog scale (rho = -0.20, p < 0.01). The CERAD-NAB scores were also significantly correlated with AD-related hypometabolism (rho = -0.49, p < 0.01). The memory domain of the ECog scale was significantly correlated with FDG uptake in the angular gyrus and posterior cingulum gyrus (rho = -0.41 and -0.46, P < 0.01). In conclusion, both total and memory domain ECog scores were correlated with the neuropsychological tests and neuroimaging biomarkers.

Original languageEnglish
Article number1719
JournalScientific Reports
Volume7
Issue number1
DOIs
StatePublished - 01 12 2017

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© 2017 The Author(s).

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