Evidence of autocrine regulation in human hepatoma cell lines

Ting Fen Tsai; Yar Khing Yauk; Chen Kung Chou; Ling Pei Ting; Chungming Chang; Hu Cheng-po; Shou Hwa Han; Tsung Sheng Su

doi:10.1016/S0006-291X(88)81186-0

Evidence of autocrine regulation in human hepatoma cell lines

Ting Fen Tsai, Yar Khing Yauk, Chen Kung Chou, Ling Pei Ting, Chungming Chang, Hu Cheng-po, Shou Hwa Han, Tsung Sheng Su^*

^*Corresponding author for this work

Research output: Contribution to journal › Journal Article › peer-review

44 Scopus citations

Abstract

Human hepatoma cell lines were studied for the expression of platelet-derived growth factor (PDGF), insulin-like growth factor-I (IGF-I) and their receptors at the mRNA level. Transcripts of PDGF were consistently detected in these cell lines. In addition, some cell lines also expressed PDGF receptor RNA. Moreover, RNA of IGF-I and its receptor were detected in every cell line examined. These results suggest that autocrine regulation may be an important mechanism for the maintenance of the transformed state of human hepatoma cells.

Original language	English
Pages (from-to)	39-45
Number of pages	7
Journal	Biochemical and Biophysical Research Communications
Volume	153
Issue number	1
DOIs	https://doi.org/10.1016/S0006-291X(88)81186-0
State	Published - 31 05 1988
Externally published	Yes

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title = "Evidence of autocrine regulation in human hepatoma cell lines",

abstract = "Human hepatoma cell lines were studied for the expression of platelet-derived growth factor (PDGF), insulin-like growth factor-I (IGF-I) and their receptors at the mRNA level. Transcripts of PDGF were consistently detected in these cell lines. In addition, some cell lines also expressed PDGF receptor RNA. Moreover, RNA of IGF-I and its receptor were detected in every cell line examined. These results suggest that autocrine regulation may be an important mechanism for the maintenance of the transformed state of human hepatoma cells.",

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AU - Tsai, Ting Fen

AU - Yauk, Yar Khing

AU - Chou, Chen Kung

AU - Ting, Ling Pei

AU - Chang, Chungming

AU - Cheng-po, Hu

AU - Han, Shou Hwa

AU - Su, Tsung Sheng

PY - 1988/5/31

Y1 - 1988/5/31

N2 - Human hepatoma cell lines were studied for the expression of platelet-derived growth factor (PDGF), insulin-like growth factor-I (IGF-I) and their receptors at the mRNA level. Transcripts of PDGF were consistently detected in these cell lines. In addition, some cell lines also expressed PDGF receptor RNA. Moreover, RNA of IGF-I and its receptor were detected in every cell line examined. These results suggest that autocrine regulation may be an important mechanism for the maintenance of the transformed state of human hepatoma cells.

AB - Human hepatoma cell lines were studied for the expression of platelet-derived growth factor (PDGF), insulin-like growth factor-I (IGF-I) and their receptors at the mRNA level. Transcripts of PDGF were consistently detected in these cell lines. In addition, some cell lines also expressed PDGF receptor RNA. Moreover, RNA of IGF-I and its receptor were detected in every cell line examined. These results suggest that autocrine regulation may be an important mechanism for the maintenance of the transformed state of human hepatoma cells.

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JO - Biochemical and Biophysical Research Communications

JF - Biochemical and Biophysical Research Communications

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ER -

Evidence of autocrine regulation in human hepatoma cell lines

Abstract

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