Excavatoids GK, new 8,17-epoxybriaranes from the cultured octocoral Briareum excavatum (Briareidae)

Ping Jyun Sung; Bo Yuan Chen; Michael Y. Chiang; Chi Hung Hou; Yin Di Su; Tsong Long Hwang; Yung Husan Chen; Jih Jung Chen

doi:10.1246/bcsj.20090306

Excavatoids GK, new 8,17-epoxybriaranes from the cultured octocoral Briareum excavatum (Briareidae)

Ping Jyun Sung^*, Bo Yuan Chen, Michael Y. Chiang, Chi Hung Hou, Yin Di Su, Tsong Long Hwang, Yung Husan Chen, Jih Jung Chen

^*Corresponding author for this work

School of Traditional Chinese Medicine

Research output: Contribution to journal › Journal Article › peer-review

14 Scopus citations

Abstract

Chemical investigations on the cultured octocoral Briareum excavatum have led to the isolation of five new 8,17-epoxybriarane diterpenoids, excavatoids GK (15). The structures of briaranes 15 were determined on the basis of spectroscopic methods and the structure of 1 was further confirmed by a single-crystal X-ray diffraction analysis. Cytotoxicity of these metabolites toward various tumor cell lines is described. Excavatoid I (3) was found to show mild inhibitory effects on elastase release and superoxide anion generation by human neutrophils.

Original language	English
Pages (from-to)	539-545
Number of pages	7
Journal	Bulletin of the Chemical Society of Japan
Volume	83
Issue number	5
DOIs	https://doi.org/10.1246/bcsj.20090306
State	Published - 2010

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title = "Excavatoids GK, new 8,17-epoxybriaranes from the cultured octocoral Briareum excavatum (Briareidae)",

abstract = "Chemical investigations on the cultured octocoral Briareum excavatum have led to the isolation of five new 8,17-epoxybriarane diterpenoids, excavatoids GK (15). The structures of briaranes 15 were determined on the basis of spectroscopic methods and the structure of 1 was further confirmed by a single-crystal X-ray diffraction analysis. Cytotoxicity of these metabolites toward various tumor cell lines is described. Excavatoid I (3) was found to show mild inhibitory effects on elastase release and superoxide anion generation by human neutrophils.",

author = "Sung, {Ping Jyun} and Chen, {Bo Yuan} and Chiang, {Michael Y.} and Hou, {Chi Hung} and Su, {Yin Di} and Hwang, {Tsong Long} and Chen, {Yung Husan} and Chen, {Jih Jung}",

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doi = "10.1246/bcsj.20090306",

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T1 - Excavatoids GK, new 8,17-epoxybriaranes from the cultured octocoral Briareum excavatum (Briareidae)

AU - Sung, Ping Jyun

AU - Chen, Bo Yuan

AU - Chiang, Michael Y.

AU - Hou, Chi Hung

AU - Su, Yin Di

AU - Hwang, Tsong Long

AU - Chen, Yung Husan

AU - Chen, Jih Jung

PY - 2010

Y1 - 2010

N2 - Chemical investigations on the cultured octocoral Briareum excavatum have led to the isolation of five new 8,17-epoxybriarane diterpenoids, excavatoids GK (15). The structures of briaranes 15 were determined on the basis of spectroscopic methods and the structure of 1 was further confirmed by a single-crystal X-ray diffraction analysis. Cytotoxicity of these metabolites toward various tumor cell lines is described. Excavatoid I (3) was found to show mild inhibitory effects on elastase release and superoxide anion generation by human neutrophils.

AB - Chemical investigations on the cultured octocoral Briareum excavatum have led to the isolation of five new 8,17-epoxybriarane diterpenoids, excavatoids GK (15). The structures of briaranes 15 were determined on the basis of spectroscopic methods and the structure of 1 was further confirmed by a single-crystal X-ray diffraction analysis. Cytotoxicity of these metabolites toward various tumor cell lines is described. Excavatoid I (3) was found to show mild inhibitory effects on elastase release and superoxide anion generation by human neutrophils.

UR - http://www.scopus.com/inward/record.url?scp=77952338844&partnerID=8YFLogxK

U2 - 10.1246/bcsj.20090306

DO - 10.1246/bcsj.20090306

M3 - 文章

AN - SCOPUS:77952338844

SN - 0009-2673

VL - 83

SP - 539

EP - 545

JO - Bulletin of the Chemical Society of Japan

JF - Bulletin of the Chemical Society of Japan

IS - 5

ER -

Excavatoids GK, new 8,17-epoxybriaranes from the cultured octocoral Briareum excavatum (Briareidae)

Abstract

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