Abstract
Chemical investigations on the cultured octocoral Briareum excavatum have led to the isolation of five new 8,17-epoxybriarane diterpenoids, excavatoids GK (15). The structures of briaranes 15 were determined on the basis of spectroscopic methods and the structure of 1 was further confirmed by a single-crystal X-ray diffraction analysis. Cytotoxicity of these metabolites toward various tumor cell lines is described. Excavatoid I (3) was found to show mild inhibitory effects on elastase release and superoxide anion generation by human neutrophils.
| Original language | English |
|---|---|
| Pages (from-to) | 539-545 |
| Number of pages | 7 |
| Journal | Bulletin of the Chemical Society of Japan |
| Volume | 83 |
| Issue number | 5 |
| DOIs | |
| State | Published - 2010 |