Exonic resequencing of the DLGAP3 gene as a candidate gene for schizophrenia

Jun Ming Li; Chao Lin Lu; Min Chih Cheng; Sy Ueng Luu; Shih Hsin Hsu; Chia Hsiang Chen

doi:10.1016/j.psychres.2012.12.015

Exonic resequencing of the DLGAP3 gene as a candidate gene for schizophrenia

Jun Ming Li, Chao Lin Lu, Min Chih Cheng^*, Sy Ueng Luu, Shih Hsin Hsu, Chia Hsiang Chen

^*Corresponding author for this work

Department of Biomedical Sciences (Master's Program in Clinical Trials Assessment)

Research output: Contribution to journal › Journal Article › peer-review

13 Scopus citations

Abstract

We resequenced the exonic regions of the DLGAP3 gene, which encodes SAP90/PSD95-associated protein 3, in 215 schizophrenic patients and 215 non-psychotic controls. Seven known single-nucleotide polymorphisms (SNPs) were identified, but not associated with schizophrenia. Nevertheless, we identified several rare missense mutations and some of them might be associated with the pathogenesis of schizophrenia.

Original language	English
Pages (from-to)	84-87
Number of pages	4
Journal	Psychiatry Research
Volume	208
Issue number	1
DOIs	https://doi.org/10.1016/j.psychres.2012.12.015
State	Published - 30 06 2013

Keywords

DLGAP3
Mutation
Schizophrenia

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.psychres.2012.12.015

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abstract = "We resequenced the exonic regions of the DLGAP3 gene, which encodes SAP90/PSD95-associated protein 3, in 215 schizophrenic patients and 215 non-psychotic controls. Seven known single-nucleotide polymorphisms (SNPs) were identified, but not associated with schizophrenia. Nevertheless, we identified several rare missense mutations and some of them might be associated with the pathogenesis of schizophrenia.",

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AU - Luu, Sy Ueng

AU - Hsu, Shih Hsin

AU - Chen, Chia Hsiang

PY - 2013/6/30

Y1 - 2013/6/30

N2 - We resequenced the exonic regions of the DLGAP3 gene, which encodes SAP90/PSD95-associated protein 3, in 215 schizophrenic patients and 215 non-psychotic controls. Seven known single-nucleotide polymorphisms (SNPs) were identified, but not associated with schizophrenia. Nevertheless, we identified several rare missense mutations and some of them might be associated with the pathogenesis of schizophrenia.

AB - We resequenced the exonic regions of the DLGAP3 gene, which encodes SAP90/PSD95-associated protein 3, in 215 schizophrenic patients and 215 non-psychotic controls. Seven known single-nucleotide polymorphisms (SNPs) were identified, but not associated with schizophrenia. Nevertheless, we identified several rare missense mutations and some of them might be associated with the pathogenesis of schizophrenia.

KW - DLGAP3

KW - Mutation

KW - Schizophrenia

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Exonic resequencing of the DLGAP3 gene as a candidate gene for schizophrenia

Abstract

Keywords

UN SDGs

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