TY - JOUR
T1 - Exploring the potential of the nano-based sunscreens and antioxidants for preventing and treating skin photoaging
AU - Lin, Chih Hung
AU - Lin, Ming Hsien
AU - Chung, Yu Kuo
AU - Alalaiwe, Ahmed
AU - Hung, Chi Feng
AU - Fang, Jia You
N1 - Copyright © 2023 Elsevier Ltd. All rights reserved.
PY - 2024/1
Y1 - 2024/1
N2 - Excessive exposure to sunlight, especially UV irradiation, causes skin photodamage. Sunscreens, such as TiO2 and ZnO, can potentially prevent UV via scattering, reflection, and absorption. Topical antioxidants are another means of skin photoprotection. Developing nanoparticles for sunscreens and antioxidants is recommended for photoaging prevention and treatment as it can improve uncomfortable skin appearance, stability, penetration, and safety. This study reviewed the effects of nano-sized sunscreens and antioxidants on skin photoprevention by examining published studies and articles from PubMed, Scopus, and Google Scholar, which explore the topics of skin photoaging, skin senescence, UV radiation, keratinocyte, dermal fibroblast, sunscreen, antioxidant, and nanoparticle. The researchers of this study also summarized the nano-based UV filters and therapeutics for mitigating skin photoaging. The skin photodamage mechanisms are presented, followed by the introduction of current skin photoaging treatment. The different nanoparticle types used for topical delivery were also explored in this study. This is followed by the mechanisms of how nanoparticles improve the UV filters and antioxidant performance. Lastly, recent investigations were reviewed on nanoparticulate sunscreens and antioxidants in skin photoaging management. Sunscreens and antioxidants for topical application have different concepts. Topical antioxidants are ideal for permeating into the skin to exhibit free radical scavenging activity, while UV filters are prescribed to remain on the skin surface without absorption to exert the UV-blocking effect without causing toxicity. The nanoparticle design strategy for meeting the different needs of sunscreens and antioxidants is also explored in this study. Although the benefits of using nanoparticles for alleviating photodamage are well-established, more animal-based and clinical studies are necessary.
AB - Excessive exposure to sunlight, especially UV irradiation, causes skin photodamage. Sunscreens, such as TiO2 and ZnO, can potentially prevent UV via scattering, reflection, and absorption. Topical antioxidants are another means of skin photoprotection. Developing nanoparticles for sunscreens and antioxidants is recommended for photoaging prevention and treatment as it can improve uncomfortable skin appearance, stability, penetration, and safety. This study reviewed the effects of nano-sized sunscreens and antioxidants on skin photoprevention by examining published studies and articles from PubMed, Scopus, and Google Scholar, which explore the topics of skin photoaging, skin senescence, UV radiation, keratinocyte, dermal fibroblast, sunscreen, antioxidant, and nanoparticle. The researchers of this study also summarized the nano-based UV filters and therapeutics for mitigating skin photoaging. The skin photodamage mechanisms are presented, followed by the introduction of current skin photoaging treatment. The different nanoparticle types used for topical delivery were also explored in this study. This is followed by the mechanisms of how nanoparticles improve the UV filters and antioxidant performance. Lastly, recent investigations were reviewed on nanoparticulate sunscreens and antioxidants in skin photoaging management. Sunscreens and antioxidants for topical application have different concepts. Topical antioxidants are ideal for permeating into the skin to exhibit free radical scavenging activity, while UV filters are prescribed to remain on the skin surface without absorption to exert the UV-blocking effect without causing toxicity. The nanoparticle design strategy for meeting the different needs of sunscreens and antioxidants is also explored in this study. Although the benefits of using nanoparticles for alleviating photodamage are well-established, more animal-based and clinical studies are necessary.
KW - Antioxidant
KW - Nanoparticle
KW - Skin delivery
KW - Skin photoaging
KW - Sunscreen
KW - Ultraviolet
KW - Antioxidants/pharmacology
KW - Skin Diseases
KW - Skin Aging
KW - Sunscreening Agents/pharmacology
KW - Animals
KW - Ultraviolet Rays
KW - Skin
UR - http://www.scopus.com/inward/record.url?scp=85177494335&partnerID=8YFLogxK
U2 - 10.1016/j.chemosphere.2023.140702
DO - 10.1016/j.chemosphere.2023.140702
M3 - 文献综述
C2 - 37979799
AN - SCOPUS:85177494335
SN - 0045-6535
VL - 347
SP - 140702
JO - Chemosphere
JF - Chemosphere
M1 - 140702
ER -
