Exploring the recognized bio-mimicry materials for gas sensing

Tzong Zeng Wu*, Yen Ren Lo, Err Cheng Chan

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

42 Scopus citations

Abstract

This study was undertaken to synthesize peptides that are partially similar to the binding sites of human olfactory receptor protein. First, a putative 3-D model structure of human olfactory receptor protein (P30953) was modeled using a molecular simulation method. The computer docking simulation was then performed to determine the most plausible binding sites between the model structure and target gases, trimethylamine, ammonia, acetic acid, and o-xylene. According to the simulation result, a series of polypeptide sequences, horp61 for TMA, horp103 for o-xylene, horp109 for ammonia, and horp193 for acetic acid as recognized molecules were designed for gas sensing purposes. Preparing these peptides as corresponding gas sensing probes, the results showed a high relative sensitivity response of 6.7 for TMA (probe horp61), 5.1 for o-xylene (probe horp103), 11 for ammonia (probe horp109), and 28 for acetic acid (probe horp193), respectively. These results indicate that peptide mimicking of binding domain on olfactory receptor opens a new window and offers a novel strategy for the further development of recognized materials for gas sensing.

Original languageEnglish
Pages (from-to)945-953
Number of pages9
JournalBiosensors and Bioelectronics
Volume16
Issue number9-12
DOIs
StatePublished - 2001

Keywords

  • Docking
  • Gas sensing probe
  • Molecular recognition
  • Olfactory receptor
  • Synthetic peptide

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