Expression of cellular retinoc acid-binding protein I is specific to neurons in adult transgenic mouse brain

Feng C. Zhou; Li Na Wei

doi:10.1016/S1567-133X(01)00010-2

Expression of cellular retinoc acid-binding protein I is specific to neurons in adult transgenic mouse brain

Feng C. Zhou^*, Li Na Wei

^*Corresponding author for this work

Research output: Contribution to journal › Journal Article › peer-review

7 Scopus citations

Abstract

Cellular retinoic acid binding protein I (CRABP-I) plays a role in retinoic acid (RA) metabolism or transport. This report shows specific neuronal expression of CRABP-I in adult transgenic mouse brain using CRABP-I promotor-driven lac-Z and neuron- and astrocyte-markers. Double staining indicates that CRABP-I is expressed in neurons and large cells (>12 μm) but to much lesser degree the astrocytes. CRABP-I-lac-Z⁺ neurons were distributed throughout the brain, but in a very discreet pattern in each brain region. CRABP-I expression in specific populations of brain neurons suggests that RA is extensively metabolized in mature brains, mostly in neurons. Additionally, the genetic basis of its specific expression in these brain areas is located in the 5′ regulatory region of this gene.

Original language	English
Pages (from-to)	67-72
Number of pages	6
Journal	Gene Expression Patterns
Volume	1
Issue number	1
DOIs	https://doi.org/10.1016/S1567-133X(01)00010-2
State	Published - 08 2001
Externally published	Yes

Keywords

Adult transgenic mouse brain
Cellular retinoic acid binding protein I
Development and regeneration
Neural plasticity
Neurotrophic factors: expression and regulation
Retinoic acid
Vitamin A

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10.1016/S1567-133X(01)00010-2

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title = "Expression of cellular retinoc acid-binding protein I is specific to neurons in adult transgenic mouse brain",

abstract = "Cellular retinoic acid binding protein I (CRABP-I) plays a role in retinoic acid (RA) metabolism or transport. This report shows specific neuronal expression of CRABP-I in adult transgenic mouse brain using CRABP-I promotor-driven lac-Z and neuron- and astrocyte-markers. Double staining indicates that CRABP-I is expressed in neurons and large cells (>12 μm) but to much lesser degree the astrocytes. CRABP-I-lac-Z+ neurons were distributed throughout the brain, but in a very discreet pattern in each brain region. CRABP-I expression in specific populations of brain neurons suggests that RA is extensively metabolized in mature brains, mostly in neurons. Additionally, the genetic basis of its specific expression in these brain areas is located in the 5′ regulatory region of this gene.",

keywords = "Adult transgenic mouse brain, Cellular retinoic acid binding protein I, Development and regeneration, Neural plasticity, Neurotrophic factors: expression and regulation, Retinoic acid, Vitamin A",

author = "Zhou, {Feng C.} and Wei, {Li Na}",

year = "2001",

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doi = "10.1016/S1567-133X(01)00010-2",

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AU - Wei, Li Na

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AB - Cellular retinoic acid binding protein I (CRABP-I) plays a role in retinoic acid (RA) metabolism or transport. This report shows specific neuronal expression of CRABP-I in adult transgenic mouse brain using CRABP-I promotor-driven lac-Z and neuron- and astrocyte-markers. Double staining indicates that CRABP-I is expressed in neurons and large cells (>12 μm) but to much lesser degree the astrocytes. CRABP-I-lac-Z+ neurons were distributed throughout the brain, but in a very discreet pattern in each brain region. CRABP-I expression in specific populations of brain neurons suggests that RA is extensively metabolized in mature brains, mostly in neurons. Additionally, the genetic basis of its specific expression in these brain areas is located in the 5′ regulatory region of this gene.

KW - Adult transgenic mouse brain

KW - Cellular retinoic acid binding protein I

KW - Development and regeneration

KW - Neural plasticity

KW - Neurotrophic factors: expression and regulation

KW - Retinoic acid

KW - Vitamin A

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Expression of cellular retinoc acid-binding protein I is specific to neurons in adult transgenic mouse brain

Abstract

Keywords

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