Expression of cytolytic mediators by synovial fluid lymphocytes in rheumatoid arthritis

Lucy H.Y. Young*, Sanjay V. Joag, Paul Y. Lin, Shue Fen Luo, Li Mou Zheng, Chau Ching Liu, John Ding E. Young

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

33 Scopus citations


To understand the role of cytolytic lymphocytes in the pathogenesis of rheumatoid arthritis, we investigated the expression of lymphocyte cytotoxicity mediators, perforin, and serine esterases, in lymphocytes derived from the synovial fluid of 15 patients with rheumatoid arthritis. Previous work has shown that CD8+ lymphocytes that possess markers of activation appear to be present in rheumatoid arthritis (RA). By means of in situ hybridization techniques and immunohistochemtcal analysis, the authors show that perform and two serine esterases (serine esterase 1/Hanukah factor/granzyme A, and serine esterase 2/granzyme B) are expressed by subpopulations of CD8+ and CD56+ lymphocytes obtained from synovial fluid. The presence of these cytotoxic mediators suggests a possible mechanism for tissue damage, and provides evidence implicating cytolytic lymphocytes in the pathogenesis of RA.

Original languageEnglish
Pages (from-to)1261-1268
Number of pages8
JournalAmerican Journal of Pathology
Issue number5
StatePublished - 05 1992
Externally publishedYes


  • Arthritis, Rheumatoid
  • Biopsy
  • Esterases
  • Female
  • Gene Expression
  • Human
  • Interleukin-2
  • Leukocytes, Mononuclear
  • Lymphocytes
  • Male
  • Membrane Proteins
  • Middle Age
  • Phenotype
  • Support, Non-U.S. Gov't
  • Support, U.S. Gov't, P.H.S.
  • Synovial Fluid
  • Synovial Membrane


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