Expression of HOXB genes is significantly different in acute myeloid leukemia with a partial tandem duplication of MLL vs. a MLL translocation: A cross-laboratory study

Hsi Che Liu; Lee Yung Shih; Mei Ju May Chen; Chien Chih Wang; Ting Chi Yeh; Tung Huei Lin; Chien Yu Chen; Chih Jen Lin; Der Cherng Liang

doi:10.1016/j.cancergen.2011.02.003

Expression of HOXB genes is significantly different in acute myeloid leukemia with a partial tandem duplication of MLL vs. a MLL translocation: A cross-laboratory study

Hsi Che Liu, Lee Yung Shih, Mei Ju May Chen, Chien Chih Wang, Ting Chi Yeh, Tung Huei Lin, Chien Yu Chen, Chih Jen Lin, Der Cherng Liang^*

^*Corresponding author for this work

Research output: Contribution to journal › Journal Article › peer-review

12 Scopus citations

Abstract

In acute myeloid leukemia (AML), the mixed lineage leukemia (. MLL) gene may be rearranged to generate a partial tandem duplication (PTD), or fused to partner genes through a chromosomal translocation (t. MLL). In this study, we first explored the differentially expressed genes between . MLL-PTD and t. MLL using gene expression profiling of our cohort (15 . MLL-PTD and 10 t. MLL) and one published data set. The top 250 probes were chosen from each set, resulting in 29 common probes (21 unique genes) to both sets. The selected genes include four . HOXB genes, . HOXB2, . B3, . B5, and . B6. The expression values of these . HOXB genes significantly differ between . MLL-PTD and t. MLL cases. Clustering and classification analyses were thoroughly conducted to support our gene selection results. Second, as . MLL-PTD, . FLT3-ITD, and . NPM1 mutations are identified in AML with normal karyotypes, we briefly studied their impact on the . HOXB genes. Another contribution of this study is to demonstrate that using public data from other studies enriches samples for analysis and yields more conclusive results.

Original language	English
Pages (from-to)	252-259
Number of pages	8
Journal	Cancer Genetics
Volume	204
Issue number	5
DOIs	https://doi.org/10.1016/j.cancergen.2011.02.003
State	Published - 05 2011
Externally published	Yes

Keywords

Acute myeloid leukemia
Gene expression profiling
HOXB genes
MLL-PTD

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.cancergen.2011.02.003

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Liu, H. C., Shih, L. Y., May Chen, M. J., Wang, C. C., Yeh, T. C., Lin, T. H., Chen, C. Y., Lin, C. J., & Liang, D. C. (2011). Expression of HOXB genes is significantly different in acute myeloid leukemia with a partial tandem duplication of MLL vs. a MLL translocation: A cross-laboratory study. Cancer Genetics, 204(5), 252-259. https://doi.org/10.1016/j.cancergen.2011.02.003

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title = "Expression of HOXB genes is significantly different in acute myeloid leukemia with a partial tandem duplication of MLL vs. a MLL translocation: A cross-laboratory study",

abstract = "In acute myeloid leukemia (AML), the mixed lineage leukemia (. MLL) gene may be rearranged to generate a partial tandem duplication (PTD), or fused to partner genes through a chromosomal translocation (t. MLL). In this study, we first explored the differentially expressed genes between . MLL-PTD and t. MLL using gene expression profiling of our cohort (15 . MLL-PTD and 10 t. MLL) and one published data set. The top 250 probes were chosen from each set, resulting in 29 common probes (21 unique genes) to both sets. The selected genes include four . HOXB genes, . HOXB2, . B3, . B5, and . B6. The expression values of these . HOXB genes significantly differ between . MLL-PTD and t. MLL cases. Clustering and classification analyses were thoroughly conducted to support our gene selection results. Second, as . MLL-PTD, . FLT3-ITD, and . NPM1 mutations are identified in AML with normal karyotypes, we briefly studied their impact on the . HOXB genes. Another contribution of this study is to demonstrate that using public data from other studies enriches samples for analysis and yields more conclusive results.",

keywords = "Acute myeloid leukemia, Gene expression profiling, HOXB genes, MLL-PTD",

author = "Liu, {Hsi Che} and Shih, {Lee Yung} and {May Chen}, {Mei Ju} and Wang, {Chien Chih} and Yeh, {Ting Chi} and Lin, {Tung Huei} and Chen, {Chien Yu} and Lin, {Chih Jen} and Liang, {Der Cherng}",

year = "2011",

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doi = "10.1016/j.cancergen.2011.02.003",

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T1 - Expression of HOXB genes is significantly different in acute myeloid leukemia with a partial tandem duplication of MLL vs. a MLL translocation

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AU - Shih, Lee Yung

AU - May Chen, Mei Ju

AU - Wang, Chien Chih

AU - Yeh, Ting Chi

AU - Lin, Tung Huei

AU - Chen, Chien Yu

AU - Lin, Chih Jen

AU - Liang, Der Cherng

PY - 2011/5

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N2 - In acute myeloid leukemia (AML), the mixed lineage leukemia (. MLL) gene may be rearranged to generate a partial tandem duplication (PTD), or fused to partner genes through a chromosomal translocation (t. MLL). In this study, we first explored the differentially expressed genes between . MLL-PTD and t. MLL using gene expression profiling of our cohort (15 . MLL-PTD and 10 t. MLL) and one published data set. The top 250 probes were chosen from each set, resulting in 29 common probes (21 unique genes) to both sets. The selected genes include four . HOXB genes, . HOXB2, . B3, . B5, and . B6. The expression values of these . HOXB genes significantly differ between . MLL-PTD and t. MLL cases. Clustering and classification analyses were thoroughly conducted to support our gene selection results. Second, as . MLL-PTD, . FLT3-ITD, and . NPM1 mutations are identified in AML with normal karyotypes, we briefly studied their impact on the . HOXB genes. Another contribution of this study is to demonstrate that using public data from other studies enriches samples for analysis and yields more conclusive results.

AB - In acute myeloid leukemia (AML), the mixed lineage leukemia (. MLL) gene may be rearranged to generate a partial tandem duplication (PTD), or fused to partner genes through a chromosomal translocation (t. MLL). In this study, we first explored the differentially expressed genes between . MLL-PTD and t. MLL using gene expression profiling of our cohort (15 . MLL-PTD and 10 t. MLL) and one published data set. The top 250 probes were chosen from each set, resulting in 29 common probes (21 unique genes) to both sets. The selected genes include four . HOXB genes, . HOXB2, . B3, . B5, and . B6. The expression values of these . HOXB genes significantly differ between . MLL-PTD and t. MLL cases. Clustering and classification analyses were thoroughly conducted to support our gene selection results. Second, as . MLL-PTD, . FLT3-ITD, and . NPM1 mutations are identified in AML with normal karyotypes, we briefly studied their impact on the . HOXB genes. Another contribution of this study is to demonstrate that using public data from other studies enriches samples for analysis and yields more conclusive results.

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KW - Gene expression profiling

KW - HOXB genes

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Expression of HOXB genes is significantly different in acute myeloid leukemia with a partial tandem duplication of MLL vs. a MLL translocation: A cross-laboratory study

Abstract

Keywords

UN SDGs

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