Expression of placenta growth factor: An independent factor for prediction of progression and prognosis of oral cancer

Shih Jung Cheng; Jang Jaer Lee; Sang Heng Kok; Chia Hsuan Chou; Hao Hueng Chang; Meng Ling Chiang; Hsin Ming Chen; Mark Yen Ping Kuo; Chun Pin Chiang

doi:10.1002/hed.21335

Expression of placenta growth factor: An independent factor for prediction of progression and prognosis of oral cancer

Shih Jung Cheng, Jang Jaer Lee, Sang Heng Kok, Chia Hsuan Chou, Hao Hueng Chang, Meng Ling Chiang, Hsin Ming Chen, Mark Yen Ping Kuo, Chun Pin Chiang^*

^*Corresponding author for this work

Research output: Contribution to journal › Journal Article › peer-review

20 Scopus citations

Abstract

Background. Expression of placenta growth factor (PlGF) is found to correlate with the progression and prognosis of several human cancers. Methods. This study used an immunohistochemical technique to examine the expression of PlGF in 100 specimens of oral squamous cell carcinoma (OSCC). Results. We found that the higher mean PlGF labeling index was significantly associated with OSCCs with positive lymph node metastasis (p =.014) or with more advanced clinical stages (p =.016). Positive lymph node metastasis (p =.008) and PlGF labeling index >40% (p =.010) were identified as independent unfavorable prognosis factors by multivariate analyses with Cox regression model. Moreover, a Kaplan-Meier curve showed that OSCC patients with a PlGF labeling index >40% had a significantly poorer cumulative survival than those with a PlGF labeling index ≤40% (log-rank test, p =.003). Conclusions. The PlGF labeling index can predict the progression and prognosis of OSCCs in Taiwan.

Original language	English
Pages (from-to)	1363-1369
Number of pages	7
Journal	Head and Neck
Volume	32
Issue number	10
DOIs	https://doi.org/10.1002/hed.21335
State	Published - 10 2010
Externally published	Yes

Keywords

cancer progression
oral cancer
placenta growth factor
prognosis

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/hed.21335

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@article{6ccc364fcaf74465b3be9b873fcd692f,

title = "Expression of placenta growth factor: An independent factor for prediction of progression and prognosis of oral cancer",

abstract = "Background. Expression of placenta growth factor (PlGF) is found to correlate with the progression and prognosis of several human cancers. Methods. This study used an immunohistochemical technique to examine the expression of PlGF in 100 specimens of oral squamous cell carcinoma (OSCC). Results. We found that the higher mean PlGF labeling index was significantly associated with OSCCs with positive lymph node metastasis (p =.014) or with more advanced clinical stages (p =.016). Positive lymph node metastasis (p =.008) and PlGF labeling index >40% (p =.010) were identified as independent unfavorable prognosis factors by multivariate analyses with Cox regression model. Moreover, a Kaplan-Meier curve showed that OSCC patients with a PlGF labeling index >40% had a significantly poorer cumulative survival than those with a PlGF labeling index ≤40% (log-rank test, p =.003). Conclusions. The PlGF labeling index can predict the progression and prognosis of OSCCs in Taiwan.",

keywords = "cancer progression, oral cancer, placenta growth factor, prognosis",

author = "Cheng, {Shih Jung} and Lee, {Jang Jaer} and Kok, {Sang Heng} and Chou, {Chia Hsuan} and Chang, {Hao Hueng} and {Ling Chiang}, Meng and Chen, {Hsin Ming} and Kuo, {Mark Yen Ping} and Chiang, {Chun Pin}",

year = "2010",

month = oct,

doi = "10.1002/hed.21335",

language = "英语",

volume = "32",

pages = "1363--1369",

journal = "Head and Neck",

issn = "1043-3074",

publisher = "John Wiley & Sons Inc.",

number = "10",

}

TY - JOUR

T1 - Expression of placenta growth factor

T2 - An independent factor for prediction of progression and prognosis of oral cancer

AU - Cheng, Shih Jung

AU - Lee, Jang Jaer

AU - Kok, Sang Heng

AU - Chou, Chia Hsuan

AU - Chang, Hao Hueng

AU - Ling Chiang, Meng

AU - Chen, Hsin Ming

AU - Kuo, Mark Yen Ping

AU - Chiang, Chun Pin

PY - 2010/10

Y1 - 2010/10

N2 - Background. Expression of placenta growth factor (PlGF) is found to correlate with the progression and prognosis of several human cancers. Methods. This study used an immunohistochemical technique to examine the expression of PlGF in 100 specimens of oral squamous cell carcinoma (OSCC). Results. We found that the higher mean PlGF labeling index was significantly associated with OSCCs with positive lymph node metastasis (p =.014) or with more advanced clinical stages (p =.016). Positive lymph node metastasis (p =.008) and PlGF labeling index >40% (p =.010) were identified as independent unfavorable prognosis factors by multivariate analyses with Cox regression model. Moreover, a Kaplan-Meier curve showed that OSCC patients with a PlGF labeling index >40% had a significantly poorer cumulative survival than those with a PlGF labeling index ≤40% (log-rank test, p =.003). Conclusions. The PlGF labeling index can predict the progression and prognosis of OSCCs in Taiwan.

AB - Background. Expression of placenta growth factor (PlGF) is found to correlate with the progression and prognosis of several human cancers. Methods. This study used an immunohistochemical technique to examine the expression of PlGF in 100 specimens of oral squamous cell carcinoma (OSCC). Results. We found that the higher mean PlGF labeling index was significantly associated with OSCCs with positive lymph node metastasis (p =.014) or with more advanced clinical stages (p =.016). Positive lymph node metastasis (p =.008) and PlGF labeling index >40% (p =.010) were identified as independent unfavorable prognosis factors by multivariate analyses with Cox regression model. Moreover, a Kaplan-Meier curve showed that OSCC patients with a PlGF labeling index >40% had a significantly poorer cumulative survival than those with a PlGF labeling index ≤40% (log-rank test, p =.003). Conclusions. The PlGF labeling index can predict the progression and prognosis of OSCCs in Taiwan.

KW - cancer progression

KW - oral cancer

KW - placenta growth factor

KW - prognosis

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U2 - 10.1002/hed.21335

DO - 10.1002/hed.21335

M3 - 文章

C2 - 20091685

AN - SCOPUS:78649463119

SN - 1043-3074

VL - 32

SP - 1363

EP - 1369

JO - Head and Neck

JF - Head and Neck

IS - 10

ER -

Expression of placenta growth factor: An independent factor for prediction of progression and prognosis of oral cancer

Abstract

Keywords

UN SDGs

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