Expression of Sox8, Sox9 and Sox10 in the developing valves and autonomic nerves of the embryonic heart

J. A. Montero, B. Giron, H. Arrechedera, Y. C. Cheng, P. Scotting, J. Chimal-Monroy, J. A. Garcia-Porrero, J. M. Hurle

Research output: Contribution to journalJournal Article peer-review

50 Scopus citations

Abstract

We describe the expression pattern of Sox8, Sox9 and Sox10 during the development of the chick embryo heart. These Sox genes constitute the group E of the large Sox family of transcription factors. We show that the expression of Sox8, Sox9 and Sox10 in the developing heart correlates with heart septation and with the differentiation of the connective tissue of the valve leaflets. Sox10 appears also as a specific marker of developing heart nerves. These findings fit with the occurrence of morphological and functional anomalies of the heart reported in humans deficient for Sox9 and Sox10.

Original languageEnglish
Pages (from-to)199-202
Number of pages4
JournalMechanisms of Development
Volume118
Issue number1-2
DOIs
StatePublished - 10 2002
Externally publishedYes

Keywords

  • Aggrecan
  • Chick embryo
  • Embryonic heart
  • Sox10
  • Sox8
  • Sox9

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