Expression profile of metastasis-related genes in invasive oral cancers

Yung Yen Chiang; Ming Hsui Tsai; Tze Yi Lin; I. Ping Chiang

Expression profile of metastasis-related genes in invasive oral cancers

Yung Yen Chiang^*, Ming Hsui Tsai, Tze Yi Lin, I. Ping Chiang

^*Corresponding author for this work

Research output: Contribution to journal › Journal Article › peer-review

17 Scopus citations

Abstract

We used suppression subtractive hybridization (SSH) and oligonucleotide microarray to differentiate expression profiles of metastasis-related genes and to evaluate their clinical significance in patients with invasive oral cancer (OCa). Overexpression of the specific genes was confirmed by reverse transcription-PCR (RT-PCR). Cells expressing the gene were identified by immunohistochemistry in pathology specimens. Clinical correlation and significance were analyzed statistically. Using these methods, we detected increased expressions of MMP-1, -3, -7, -9, -10 and interleukin (IL)-8 in invasive OCa. Moreover, our data showed that overexpressions of MMP-1, -3, -7, -10 and IL-8 were associated with reduced survival.

Original language	English
Pages (from-to)	1213-1222
Number of pages	10
Journal	Histology and Histopathology
Volume	23
Issue number	10
State	Published - 2008
Externally published	Yes

Keywords

Matrix metalloproteinase
Oral cancer
Prognosis

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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title = "Expression profile of metastasis-related genes in invasive oral cancers",

abstract = "We used suppression subtractive hybridization (SSH) and oligonucleotide microarray to differentiate expression profiles of metastasis-related genes and to evaluate their clinical significance in patients with invasive oral cancer (OCa). Overexpression of the specific genes was confirmed by reverse transcription-PCR (RT-PCR). Cells expressing the gene were identified by immunohistochemistry in pathology specimens. Clinical correlation and significance were analyzed statistically. Using these methods, we detected increased expressions of MMP-1, -3, -7, -9, -10 and interleukin (IL)-8 in invasive OCa. Moreover, our data showed that overexpressions of MMP-1, -3, -7, -10 and IL-8 were associated with reduced survival.",

keywords = "Matrix metalloproteinase, Oral cancer, Prognosis",

author = "Chiang, {Yung Yen} and Tsai, {Ming Hsui} and Lin, {Tze Yi} and Chiang, {I. Ping}",

year = "2008",

language = "英语",

volume = "23",

pages = "1213--1222",

journal = "Histology and Histopathology",

issn = "0213-3911",

publisher = "Histology and Histopathology",

number = "10",

}

TY - JOUR

T1 - Expression profile of metastasis-related genes in invasive oral cancers

AU - Chiang, Yung Yen

AU - Tsai, Ming Hsui

AU - Lin, Tze Yi

AU - Chiang, I. Ping

PY - 2008

Y1 - 2008

N2 - We used suppression subtractive hybridization (SSH) and oligonucleotide microarray to differentiate expression profiles of metastasis-related genes and to evaluate their clinical significance in patients with invasive oral cancer (OCa). Overexpression of the specific genes was confirmed by reverse transcription-PCR (RT-PCR). Cells expressing the gene were identified by immunohistochemistry in pathology specimens. Clinical correlation and significance were analyzed statistically. Using these methods, we detected increased expressions of MMP-1, -3, -7, -9, -10 and interleukin (IL)-8 in invasive OCa. Moreover, our data showed that overexpressions of MMP-1, -3, -7, -10 and IL-8 were associated with reduced survival.

AB - We used suppression subtractive hybridization (SSH) and oligonucleotide microarray to differentiate expression profiles of metastasis-related genes and to evaluate their clinical significance in patients with invasive oral cancer (OCa). Overexpression of the specific genes was confirmed by reverse transcription-PCR (RT-PCR). Cells expressing the gene were identified by immunohistochemistry in pathology specimens. Clinical correlation and significance were analyzed statistically. Using these methods, we detected increased expressions of MMP-1, -3, -7, -9, -10 and interleukin (IL)-8 in invasive OCa. Moreover, our data showed that overexpressions of MMP-1, -3, -7, -10 and IL-8 were associated with reduced survival.

KW - Matrix metalloproteinase

KW - Oral cancer

KW - Prognosis

UR - http://www.scopus.com/inward/record.url?scp=54449102386&partnerID=8YFLogxK

M3 - 文章

C2 - 18712673

AN - SCOPUS:54449102386

SN - 0213-3911

VL - 23

SP - 1213

EP - 1222

JO - Histology and Histopathology

JF - Histology and Histopathology

IS - 10

ER -

Expression profile of metastasis-related genes in invasive oral cancers

Abstract

Keywords

UN SDGs

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