Extended pain relief achieved by analgesic-eluting biodegradable nanofibers in the Nuss procedure: In vitro and in vivo studies

Kuo Sheng Liu, Wei Hsun Chen, Cheng Hung Lee, Yong Fong Su, Shih Jung Liu*

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

6 Scopus citations


Background: The most common complaint after the Nuss procedure is severe postoperative chest pain. The aim of this study was to evaluate the effectiveness of analgesic-eluting biodegradable nanofibers in pain relief after the Nuss procedure. Materials and methods: Poly(D,L)-lactide-co-glycolide, lidocaine, and ketorolac were dissolved in 1,1,1,3,3,3-hexafluoro-2-propanol. This solution was electrospun into a nanofibrous membrane. The elution method and high-performance chromatography were used to characterize the in vitro drug release. Stainless steel bars with and without coating of the analgesic-eluting nanofibrous membrane were implanted underneath the sternums of New Zealand white rabbits. The in vivo characteristics were further investigated. Results: The in vitro study showed that the biodegradable nanofibers released high doses of lidocaine and ketorolac within 10 days. The in vivo study demonstrated high local and systemic concentrations of lidocaine and ketorolac. The serum creatinine level was unaffected. Animals that received implants of the analgesic-eluting nanofiber-coated stainless steel bar exhibited significantly greater food and water ingestion and physical activity than the control group did, indicating effective pain relief. Conclusion: The proposed analgesic-eluting biodegradable nanofibers contribute to the achievement of extended pain relief after the Nuss procedure, without obvious adverse effects, in an animal model.

Original languageEnglish
Pages (from-to)8355-8364
Number of pages10
JournalInternational Journal of Nanomedicine
StatePublished - 2018

Bibliographical note

Publisher Copyright:
© 2018 Liu et al.


  • Analgesic-eluting
  • Biodegradable
  • Nanofibers
  • Nuss procedure
  • Pectus excavatum


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