Extranodal NK/T-cell lymphoma: Toward the identification of clinical molecular targets

Christian Schmitt*, Nouhoum Sako, Martine Bagot, Yenlin Huang, Philippe Gaulard, Armand Bensussan

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

15 Scopus citations

Abstract

Extranodal natural killer (NK)/T-cell lymphoma of nasal type (NKTCL) is a malignant disorder of cytotoxic lymphocytes of NK or more rarely T cells associated with clonal Epstein-Barr virus infection. Extranodal NKTCL is rare in Western countries, but in Asia and Central and South America it can account for up to 10 of non-Hodgkin's lymphomas. It is an aggressive neoplasm with very poor prognosis. Although the pathogenesis of extranodal NKTCL remains poorly understood, some insights have been gained in the recent years, especially from genome-wide studies. Based on our own experience and knowledge of the literature, we here review some of the genomic and functional pathway alterations observed in NKTCL that could provide a rationale for the development of innovative therapeutic strategies.

Original languageEnglish
Article number790871
JournalJournal of Biomedicine and Biotechnology
Volume2011
DOIs
StatePublished - 2011
Externally publishedYes

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