F4/80 and the related adhesion-GPCRs

Siamon Gordon*, Jörg Hamann, Hsi Hsien Lin, Martin Stacey

*Corresponding author for this work

Research output: Contribution to journalComment/debate

118 Scopus citations


The F4/80 monoclonal antibody was first reported in this journal 30 years ago (Eur. J. Immunol. 1981. 11: 805-815). F4/80 has become a widely used marker for monocytes and many, but not all, tissue macrophages in the mouse. F4/80 is a member of the EGF-TM7 family of leukocyte plasma membrane heptahelical molecules, which includes CD97 and EMR2. This Viewpoint summarises current knowledge of the expression, structure and functions of the EGF-TM7 family, as part of a larger family of tissue adhesion-GPCRs.

Original languageEnglish
Pages (from-to)2472-2476
Number of pages5
JournalEuropean Journal of Immunology
Issue number9
StatePublished - 09 2011


  • Adhesion-GPCRs
  • EGF-TM7 family
  • Macrophages


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