Abstract
The F4/80 monoclonal antibody was first reported in this journal 30 years ago (Eur. J. Immunol. 1981. 11: 805-815). F4/80 has become a widely used marker for monocytes and many, but not all, tissue macrophages in the mouse. F4/80 is a member of the EGF-TM7 family of leukocyte plasma membrane heptahelical molecules, which includes CD97 and EMR2. This Viewpoint summarises current knowledge of the expression, structure and functions of the EGF-TM7 family, as part of a larger family of tissue adhesion-GPCRs.
Original language | English |
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Pages (from-to) | 2472-2476 |
Number of pages | 5 |
Journal | European Journal of Immunology |
Volume | 41 |
Issue number | 9 |
DOIs |
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State | Published - 09 2011 |
Keywords
- Adhesion-GPCRs
- EGF-TM7 family
- Macrophages