F4/80 and the related adhesion-GPCRs

Siamon Gordon; Jörg Hamann; Hsi Hsien Lin; Martin Stacey

doi:10.1002/eji.201141715

F4/80 and the related adhesion-GPCRs

Siamon Gordon^*
, Jörg Hamann
, Hsi Hsien Lin
, Martin Stacey

^*Corresponding author for this work

Department of Microbiology and Immunology

Research output: Contribution to journal › Comment/debate

131 Scopus citations

Abstract

The F4/80 monoclonal antibody was first reported in this journal 30 years ago (Eur. J. Immunol. 1981. 11: 805-815). F4/80 has become a widely used marker for monocytes and many, but not all, tissue macrophages in the mouse. F4/80 is a member of the EGF-TM7 family of leukocyte plasma membrane heptahelical molecules, which includes CD97 and EMR2. This Viewpoint summarises current knowledge of the expression, structure and functions of the EGF-TM7 family, as part of a larger family of tissue adhesion-GPCRs.

Original language	English
Pages (from-to)	2472-2476
Number of pages	5
Journal	European Journal of Immunology
Volume	41
Issue number	9
DOIs	https://doi.org/10.1002/eji.201141715
State	Published - 09 2011

Keywords

Adhesion-GPCRs
EGF-TM7 family
Macrophages

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title = "F4/80 and the related adhesion-GPCRs",

abstract = "The F4/80 monoclonal antibody was first reported in this journal 30 years ago (Eur. J. Immunol. 1981. 11: 805-815). F4/80 has become a widely used marker for monocytes and many, but not all, tissue macrophages in the mouse. F4/80 is a member of the EGF-TM7 family of leukocyte plasma membrane heptahelical molecules, which includes CD97 and EMR2. This Viewpoint summarises current knowledge of the expression, structure and functions of the EGF-TM7 family, as part of a larger family of tissue adhesion-GPCRs.",

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author = "Siamon Gordon and J{\"o}rg Hamann and Lin, \{Hsi Hsien\} and Martin Stacey",

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doi = "10.1002/eji.201141715",

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AU - Gordon, Siamon

AU - Hamann, Jörg

AU - Lin, Hsi Hsien

AU - Stacey, Martin

PY - 2011/9

Y1 - 2011/9

N2 - The F4/80 monoclonal antibody was first reported in this journal 30 years ago (Eur. J. Immunol. 1981. 11: 805-815). F4/80 has become a widely used marker for monocytes and many, but not all, tissue macrophages in the mouse. F4/80 is a member of the EGF-TM7 family of leukocyte plasma membrane heptahelical molecules, which includes CD97 and EMR2. This Viewpoint summarises current knowledge of the expression, structure and functions of the EGF-TM7 family, as part of a larger family of tissue adhesion-GPCRs.

AB - The F4/80 monoclonal antibody was first reported in this journal 30 years ago (Eur. J. Immunol. 1981. 11: 805-815). F4/80 has become a widely used marker for monocytes and many, but not all, tissue macrophages in the mouse. F4/80 is a member of the EGF-TM7 family of leukocyte plasma membrane heptahelical molecules, which includes CD97 and EMR2. This Viewpoint summarises current knowledge of the expression, structure and functions of the EGF-TM7 family, as part of a larger family of tissue adhesion-GPCRs.

KW - Adhesion-GPCRs

KW - EGF-TM7 family

KW - Macrophages

UR - https://www.scopus.com/pages/publications/80052174108

U2 - 10.1002/eji.201141715

DO - 10.1002/eji.201141715

M3 - 评论/辩论

C2 - 21952799

AN - SCOPUS:80052174108

SN - 0014-2980

VL - 41

SP - 2472

EP - 2476

JO - European Journal of Immunology

JF - European Journal of Immunology

IS - 9

ER -

F4/80 and the related adhesion-GPCRs

Abstract

Keywords

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