Fabrication of triple layered vascular scaffolds by combining electrospinning, braiding, and thermally induced phase separation

Hao Yang Mi; Xin Jing; Emily Yu; Jason McNulty; Lih Sheng Turng

doi:10.1063/1.4937310

Fabrication of triple layered vascular scaffolds by combining electrospinning, braiding, and thermally induced phase separation

Hao Yang Mi, Xin Jing, Emily Yu, Jason McNulty, Lih Sheng Turng^*

^*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

Abstract

Triple layered small diameter vascular scaffolds, which consisted of thermoplastic polyurethane (TPU) and silk, were fabricated in this study for the first time by combining electrospinning, braiding, and thermally induced phase separation methods. These novel vascular scaffolds, which possess three layers of different structures (nanofibrous inner layer, woven silk filament middle layer, and porous outer layer) have a desired toe region in the tensile test and sufficient suture retention and burst pressure for vascular graft applications. The endothelia cell culture tests showed that a cell layer could form on the inner surface of a scaffold with high cell viability. Furthermore, the cells showed favorable morphology on the scaffold.

Original language	English
Title of host publication	Polymer Processing with Resulting Morphology and Properties
Subtitle of host publication	Feet in the Present and Eyes at the Future: Proceedings of the GT70 International Conference
Editors	Roberto Pantani, Vito Speranza, Felice De Santis
Publisher	American Institute of Physics Inc.
ISBN (Electronic)	9780735413429
DOIs	https://doi.org/10.1063/1.4937310
State	Published - 17 12 2015
Externally published	Yes
Event	International Conference on Polymer Processing with Resulting Morphology and Properties: Feet in the Present and Eyes at the Future, GT 2015 - Salerno, Italy Duration: 15 10 2015 → 17 10 2015

Publication series

Name	AIP Conference Proceedings
Volume	1695
ISSN (Print)	0094-243X
ISSN (Electronic)	1551-7616

Conference

Conference	International Conference on Polymer Processing with Resulting Morphology and Properties: Feet in the Present and Eyes at the Future, GT 2015
Country/Territory	Italy
City	Salerno
Period	15/10/15 → 17/10/15

Bibliographical note

Publisher Copyright:
© 2015 AIP Publishing LLC.

Access to Document

10.1063/1.4937310

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Mi, H. Y., Jing, X., Yu, E., McNulty, J., & Turng, L. S. (2015). Fabrication of triple layered vascular scaffolds by combining electrospinning, braiding, and thermally induced phase separation. In R. Pantani, V. Speranza, & F. De Santis (Eds.), Polymer Processing with Resulting Morphology and Properties: Feet in the Present and Eyes at the Future: Proceedings of the GT70 International Conference Article 020032 (AIP Conference Proceedings; Vol. 1695). American Institute of Physics Inc.. https://doi.org/10.1063/1.4937310

Mi, Hao Yang ; Jing, Xin ; Yu, Emily et al. / Fabrication of triple layered vascular scaffolds by combining electrospinning, braiding, and thermally induced phase separation. Polymer Processing with Resulting Morphology and Properties: Feet in the Present and Eyes at the Future: Proceedings of the GT70 International Conference. editor / Roberto Pantani ; Vito Speranza ; Felice De Santis. American Institute of Physics Inc., 2015. (AIP Conference Proceedings).

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title = "Fabrication of triple layered vascular scaffolds by combining electrospinning, braiding, and thermally induced phase separation",

abstract = "Triple layered small diameter vascular scaffolds, which consisted of thermoplastic polyurethane (TPU) and silk, were fabricated in this study for the first time by combining electrospinning, braiding, and thermally induced phase separation methods. These novel vascular scaffolds, which possess three layers of different structures (nanofibrous inner layer, woven silk filament middle layer, and porous outer layer) have a desired toe region in the tensile test and sufficient suture retention and burst pressure for vascular graft applications. The endothelia cell culture tests showed that a cell layer could form on the inner surface of a scaffold with high cell viability. Furthermore, the cells showed favorable morphology on the scaffold.",

author = "Mi, {Hao Yang} and Xin Jing and Emily Yu and Jason McNulty and Turng, {Lih Sheng}",

note = "Publisher Copyright: {\textcopyright} 2015 AIP Publishing LLC.; International Conference on Polymer Processing with Resulting Morphology and Properties: Feet in the Present and Eyes at the Future, GT 2015 ; Conference date: 15-10-2015 Through 17-10-2015",

year = "2015",

month = dec,

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doi = "10.1063/1.4937310",

language = "英语",

series = "AIP Conference Proceedings",

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Mi, HY, Jing, X, Yu, E, McNulty, J & Turng, LS 2015, Fabrication of triple layered vascular scaffolds by combining electrospinning, braiding, and thermally induced phase separation. in R Pantani, V Speranza & F De Santis (eds), Polymer Processing with Resulting Morphology and Properties: Feet in the Present and Eyes at the Future: Proceedings of the GT70 International Conference., 020032, AIP Conference Proceedings, vol. 1695, American Institute of Physics Inc., International Conference on Polymer Processing with Resulting Morphology and Properties: Feet in the Present and Eyes at the Future, GT 2015, Salerno, Italy, 15/10/15. https://doi.org/10.1063/1.4937310

Fabrication of triple layered vascular scaffolds by combining electrospinning, braiding, and thermally induced phase separation. / Mi, Hao Yang; Jing, Xin; Yu, Emily et al.
Polymer Processing with Resulting Morphology and Properties: Feet in the Present and Eyes at the Future: Proceedings of the GT70 International Conference. ed. / Roberto Pantani; Vito Speranza; Felice De Santis. American Institute of Physics Inc., 2015. 020032 (AIP Conference Proceedings; Vol. 1695).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

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T1 - Fabrication of triple layered vascular scaffolds by combining electrospinning, braiding, and thermally induced phase separation

AU - Mi, Hao Yang

AU - Jing, Xin

AU - Yu, Emily

AU - McNulty, Jason

AU - Turng, Lih Sheng

PY - 2015/12/17

Y1 - 2015/12/17

N2 - Triple layered small diameter vascular scaffolds, which consisted of thermoplastic polyurethane (TPU) and silk, were fabricated in this study for the first time by combining electrospinning, braiding, and thermally induced phase separation methods. These novel vascular scaffolds, which possess three layers of different structures (nanofibrous inner layer, woven silk filament middle layer, and porous outer layer) have a desired toe region in the tensile test and sufficient suture retention and burst pressure for vascular graft applications. The endothelia cell culture tests showed that a cell layer could form on the inner surface of a scaffold with high cell viability. Furthermore, the cells showed favorable morphology on the scaffold.

AB - Triple layered small diameter vascular scaffolds, which consisted of thermoplastic polyurethane (TPU) and silk, were fabricated in this study for the first time by combining electrospinning, braiding, and thermally induced phase separation methods. These novel vascular scaffolds, which possess three layers of different structures (nanofibrous inner layer, woven silk filament middle layer, and porous outer layer) have a desired toe region in the tensile test and sufficient suture retention and burst pressure for vascular graft applications. The endothelia cell culture tests showed that a cell layer could form on the inner surface of a scaffold with high cell viability. Furthermore, the cells showed favorable morphology on the scaffold.

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BT - Polymer Processing with Resulting Morphology and Properties

A2 - Pantani, Roberto

A2 - Speranza, Vito

A2 - De Santis, Felice

PB - American Institute of Physics Inc.

T2 - International Conference on Polymer Processing with Resulting Morphology and Properties: Feet in the Present and Eyes at the Future, GT 2015

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ER -

Mi HY, Jing X, Yu E, McNulty J, Turng LS. Fabrication of triple layered vascular scaffolds by combining electrospinning, braiding, and thermally induced phase separation. In Pantani R, Speranza V, De Santis F, editors, Polymer Processing with Resulting Morphology and Properties: Feet in the Present and Eyes at the Future: Proceedings of the GT70 International Conference. American Institute of Physics Inc. 2015. 020032. (AIP Conference Proceedings). doi: 10.1063/1.4937310

Fabrication of triple layered vascular scaffolds by combining electrospinning, braiding, and thermally induced phase separation

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