Facile synthesis of hexagonal-shaped zinc doped cobalt oxide: Application for electroanalytical determination of antibacterial drug ofloxacin in urine samples

Natesan Manjula, Tse Wei Chen, Shen Ming Chen*, Bih Show Lou

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

12 Scopus citations

Abstract

Ofloxacin (OFX) is one of the antibacterial drugs is used to treat bacterial infections including bronchitis, chlamydia, pneumonia, skin infections, prostatic and urinary tract infections, etc. Conversely, improper use of OFX can rise the tensile strength of the bacteria. To reduce the risk of human intoxication and to avoid severe effects in the environment, the trace level determination of ofloxacin is very significant, it must be very cheap and accurate. Herein, we prepared the hexagonal-shaped Zn-Co3O4 by simple and facile coprecipitation approach, and it's employed as an effective electrocatalyst for the OFX sensor. The physical and chemical properties of Zn-Co3O4 characterized by XRD, FE-SEM, FTIR, and TEM. CV and DPV were applied to monitoring the electrochemical characterization. The Zn-Co3O4 shows the high electrocatalytic activity towards the OFX detection and it proved in our results. Especially, the proposed material required the ultralow potential (0.87 V) for OFX detection. The sensor displays the dynamic linear range of 1.5–110 µM with a low detection limit of 0.04 µM (S/N = 3). The proposed sensor is also displaying excellent stability, good anti-interference ability, and reusable. The Zn-Co3O4 modified electrode was applied to the OFX detection in human urine samples for real-time application with acceptable recovery results. In our result, we comment the Zn-Co3O4 is a promising electrode material for the OFX sensor.

Original languageEnglish
Article number115101
JournalJournal of Electroanalytical Chemistry
Volume885
DOIs
StatePublished - 15 03 2021

Bibliographical note

Publisher Copyright:
© 2021 Elsevier B.V.

Keywords

  • Bacterial infection
  • Differential pulse voltammetry
  • Hexagonal shape
  • Ofloxacin
  • Zinc-cobalt oxide

Fingerprint

Dive into the research topics of 'Facile synthesis of hexagonal-shaped zinc doped cobalt oxide: Application for electroanalytical determination of antibacterial drug ofloxacin in urine samples'. Together they form a unique fingerprint.

Cite this