Facilitation of baroreceptor reflex response by endogenous somatostatin in the rat

Shyun Shyun Lin, Julie Y.H. Chan*, Samuel H.H. Chan

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

14 Scopus citations


We evaluated the potential participation of endogenous brain somatostatin-14 (SOM) in central cardiovascular regulation, using adult male Sprague-Dawley rats anesthetized with pentobarbital sodium (40 mg/kg, i.p.). Intracerebroventricular (i.c.v.) application of SOM (2 or 4 nmol) promoted a significant elevation in baroreceptor reflex (BRR) response, induced by phenylephrine (5 μg/kg, i.v.). Blocking the endogenous SOM activity with its specific receptor antagonist, cyclo-[7-aminoheptanoyl-Phe-d-Trp-Lys-Thr(Bzl)] (2 or 4 nmol, i.c.v.) or antiserum against SOM (1 : 20, i.c.v.), on the other hand, appreciably attenuated the same response. These modulatory effects on the BRR response were essentially duplicated upon bilateral microinjections of SOM (320 pmol), SOM antagonist (320 pmol) or anti-SOM (1 : 20) into the caudal portion of the nucleus of tractus solitarius (NTS), the terminal site for baroreceptor afferents. These results suggest that neurons that contain SOM may participate in cardiovascular control by tonically facilitating the BRR, possibly by exerting an influence on the neurons at the NTS.

Original languageEnglish
Pages (from-to)239-250
Number of pages12
JournalRegulatory Peptides
Issue number3
StatePublished - 17 05 1991
Externally publishedYes


  • Baroreceptor reflex
  • Nucleus of tractus solitarius
  • Rat
  • Somatostatin
  • Somatostatin antagonist and antiserum


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