Family-based association study between brain-derived neurotrophic factor gene polymorphisms and attention deficit hyperactivity disorder in UK and Taiwanese samples

Xiaohui Xu; Jonathan Mill; Kaixin Zhou; Keeley Brookes; Chih Ken Chen; Philip Asherson

doi:10.1002/ajmg.b.30406

Family-based association study between brain-derived neurotrophic factor gene polymorphisms and attention deficit hyperactivity disorder in UK and Taiwanese samples

Xiaohui Xu^*
, Jonathan Mill
, Kaixin Zhou
, Keeley Brookes
, Chih Ken Chen
, Philip Asherson

^*Corresponding author for this work

School of Medicine

King's College London

Research output: Contribution to journal › Journal Article › peer-review

52 Scopus citations

Abstract

Brain-derived neurotrophic factor (BDNF) plays an important role in normal neuronal development. Several lines of evidence implicate the involvement of BDNF in attention-deficit hyperactivity disorder (ADHD). This study investigated the role of two common BDNF variants (Val66Met, C270T) in two samples of ADHD probands from the United Kingdom (n = 180) and Taiwan (n = 212). We found evidence of increased transmission of the C allele of the C270T in Taiwanese samples (TDT: χx² = 6.78, P = 0.009) and the two samples pooled together (TDT: χx² = 7.24, P = 0.007). No association was found between the Val66Met polymorphism and ADHD in either of the two populations. Analysis of haplotypes demonstrated a significant decreased transmission of haplotypes containing the Val66 allele and the 270T allele in the Taiwanese samples (TDT: χx² = 4.57, P = 0.032) and the pooled sample set (TDT: χx² = 5.82, P = 0.016). This study provides evidence for the possible involvement of BDNF in susceptibility to ADHD.

Original language	English
Pages (from-to)	83-86
Number of pages	4
Journal	American Journal of Medical Genetics - Neuropsychiatric Genetics
Volume	144
Issue number	1
DOIs	https://doi.org/10.1002/ajmg.b.30406
State	Published - 05 01 2007

Keywords

Association studies
Attention-deficit hyperactivity disorder (ADHD)
Brain-derived neurotrophic factor (BDNF)
Single nucleotide polymorphism (SNP)

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10.1002/ajmg.b.30406

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title = "Family-based association study between brain-derived neurotrophic factor gene polymorphisms and attention deficit hyperactivity disorder in UK and Taiwanese samples",

abstract = "Brain-derived neurotrophic factor (BDNF) plays an important role in normal neuronal development. Several lines of evidence implicate the involvement of BDNF in attention-deficit hyperactivity disorder (ADHD). This study investigated the role of two common BDNF variants (Val66Met, C270T) in two samples of ADHD probands from the United Kingdom (n = 180) and Taiwan (n = 212). We found evidence of increased transmission of the C allele of the C270T in Taiwanese samples (TDT: χx2 = 6.78, P = 0.009) and the two samples pooled together (TDT: χx2 = 7.24, P = 0.007). No association was found between the Val66Met polymorphism and ADHD in either of the two populations. Analysis of haplotypes demonstrated a significant decreased transmission of haplotypes containing the Val66 allele and the 270T allele in the Taiwanese samples (TDT: χx2 = 4.57, P = 0.032) and the pooled sample set (TDT: χx2 = 5.82, P = 0.016). This study provides evidence for the possible involvement of BDNF in susceptibility to ADHD.",

keywords = "Association studies, Attention-deficit hyperactivity disorder (ADHD), Brain-derived neurotrophic factor (BDNF), Single nucleotide polymorphism (SNP)",

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Family-based association study between brain-derived neurotrophic factor gene polymorphisms and attention deficit hyperactivity disorder in UK and Taiwanese samples. / Xu, Xiaohui; Mill, Jonathan; Zhou, Kaixin et al.
In: American Journal of Medical Genetics - Neuropsychiatric Genetics, Vol. 144, No. 1, 05.01.2007, p. 83-86.

Research output: Contribution to journal › Journal Article › peer-review

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AU - Mill, Jonathan

AU - Zhou, Kaixin

AU - Brookes, Keeley

AU - Chen, Chih Ken

AU - Asherson, Philip

PY - 2007/1/5

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AB - Brain-derived neurotrophic factor (BDNF) plays an important role in normal neuronal development. Several lines of evidence implicate the involvement of BDNF in attention-deficit hyperactivity disorder (ADHD). This study investigated the role of two common BDNF variants (Val66Met, C270T) in two samples of ADHD probands from the United Kingdom (n = 180) and Taiwan (n = 212). We found evidence of increased transmission of the C allele of the C270T in Taiwanese samples (TDT: χx2 = 6.78, P = 0.009) and the two samples pooled together (TDT: χx2 = 7.24, P = 0.007). No association was found between the Val66Met polymorphism and ADHD in either of the two populations. Analysis of haplotypes demonstrated a significant decreased transmission of haplotypes containing the Val66 allele and the 270T allele in the Taiwanese samples (TDT: χx2 = 4.57, P = 0.032) and the pooled sample set (TDT: χx2 = 5.82, P = 0.016). This study provides evidence for the possible involvement of BDNF in susceptibility to ADHD.

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Family-based association study between brain-derived neurotrophic factor gene polymorphisms and attention deficit hyperactivity disorder in UK and Taiwanese samples

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