Fatal sodium valproate-induced hypersensitivity syndrome with lichenoid dermatitis and fulminant hepatitis

Yau Li Huang; Hong Shang Hong; Zen Whe Wang; Tseng tong Kuo

doi:10.1067/S0190-9622(03)00748-5

Fatal sodium valproate-induced hypersensitivity syndrome with lichenoid dermatitis and fulminant hepatitis

Yau Li Huang, Hong Shang Hong, Zen Whe Wang^*, Tseng tong Kuo

^*Corresponding author for this work

Chang Gung Memorial Hospital

Research output: Contribution to journal › Journal Article › peer-review

26 Scopus citations

Abstract

Anticonvulsant hypersensitivity syndrome caused by sodium valproate (Depakene) has rarely been reported. Here we describe a patient who presented with nonspecific polymorphous eruptions, fulminant hepatitis, and jaundice. Lichenoid dermatitis was found in the skin biopsy specimen. Toxic hepatitis and microvesicular steatosis were found in the liver biopsy specimen, consistent with valproate hepatotoxicity.

Original language	English
Pages (from-to)	316-319
Number of pages	4
Journal	Journal of the American Academy of Dermatology
Volume	49
Issue number	2
DOIs	https://doi.org/10.1067/S0190-9622(03)00748-5
State	Published - 01 08 2003
Externally published	Yes

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10.1067/S0190-9622(03)00748-5

Cite this

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abstract = "Anticonvulsant hypersensitivity syndrome caused by sodium valproate (Depakene) has rarely been reported. Here we describe a patient who presented with nonspecific polymorphous eruptions, fulminant hepatitis, and jaundice. Lichenoid dermatitis was found in the skin biopsy specimen. Toxic hepatitis and microvesicular steatosis were found in the liver biopsy specimen, consistent with valproate hepatotoxicity.",

author = "Huang, {Yau Li} and Hong, {Hong Shang} and Wang, {Zen Whe} and Kuo, {Tseng tong}",

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AU - Hong, Hong Shang

AU - Wang, Zen Whe

AU - Kuo, Tseng tong

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Y1 - 2003/8/1

N2 - Anticonvulsant hypersensitivity syndrome caused by sodium valproate (Depakene) has rarely been reported. Here we describe a patient who presented with nonspecific polymorphous eruptions, fulminant hepatitis, and jaundice. Lichenoid dermatitis was found in the skin biopsy specimen. Toxic hepatitis and microvesicular steatosis were found in the liver biopsy specimen, consistent with valproate hepatotoxicity.

AB - Anticonvulsant hypersensitivity syndrome caused by sodium valproate (Depakene) has rarely been reported. Here we describe a patient who presented with nonspecific polymorphous eruptions, fulminant hepatitis, and jaundice. Lichenoid dermatitis was found in the skin biopsy specimen. Toxic hepatitis and microvesicular steatosis were found in the liver biopsy specimen, consistent with valproate hepatotoxicity.

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M3 - 文章

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AN - SCOPUS:0042133150

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ER -

Fatal sodium valproate-induced hypersensitivity syndrome with lichenoid dermatitis and fulminant hepatitis

Abstract

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