Fatal sodium valproate-induced hypersensitivity syndrome with lichenoid dermatitis and fulminant hepatitis

Yau Li Huang; Hong Shang Hong; Zen Whe Wang; Tseng tong Kuo

doi:10.1067/S0190-9622(03)00748-5

Fatal sodium valproate-induced hypersensitivity syndrome with lichenoid dermatitis and fulminant hepatitis

Yau Li Huang
, Hong Shang Hong
, Zen Whe Wang^*
, Tseng tong Kuo

^*Corresponding author for this work

Chang Gung Memorial Hospital

Research output: Contribution to journal › Journal Article › peer-review

27 Scopus citations

Abstract

Anticonvulsant hypersensitivity syndrome caused by sodium valproate (Depakene) has rarely been reported. Here we describe a patient who presented with nonspecific polymorphous eruptions, fulminant hepatitis, and jaundice. Lichenoid dermatitis was found in the skin biopsy specimen. Toxic hepatitis and microvesicular steatosis were found in the liver biopsy specimen, consistent with valproate hepatotoxicity.

Original language	English
Pages (from-to)	316-319
Number of pages	4
Journal	Journal of the American Academy of Dermatology
Volume	49
Issue number	2
DOIs	https://doi.org/10.1067/S0190-9622(03)00748-5
State	Published - 01 08 2003
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.1067/S0190-9622(03)00748-5

Cite this

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title = "Fatal sodium valproate-induced hypersensitivity syndrome with lichenoid dermatitis and fulminant hepatitis",

abstract = "Anticonvulsant hypersensitivity syndrome caused by sodium valproate (Depakene) has rarely been reported. Here we describe a patient who presented with nonspecific polymorphous eruptions, fulminant hepatitis, and jaundice. Lichenoid dermatitis was found in the skin biopsy specimen. Toxic hepatitis and microvesicular steatosis were found in the liver biopsy specimen, consistent with valproate hepatotoxicity.",

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AU - Huang, Yau Li

AU - Hong, Hong Shang

AU - Wang, Zen Whe

AU - Kuo, Tseng tong

PY - 2003/8/1

Y1 - 2003/8/1

N2 - Anticonvulsant hypersensitivity syndrome caused by sodium valproate (Depakene) has rarely been reported. Here we describe a patient who presented with nonspecific polymorphous eruptions, fulminant hepatitis, and jaundice. Lichenoid dermatitis was found in the skin biopsy specimen. Toxic hepatitis and microvesicular steatosis were found in the liver biopsy specimen, consistent with valproate hepatotoxicity.

AB - Anticonvulsant hypersensitivity syndrome caused by sodium valproate (Depakene) has rarely been reported. Here we describe a patient who presented with nonspecific polymorphous eruptions, fulminant hepatitis, and jaundice. Lichenoid dermatitis was found in the skin biopsy specimen. Toxic hepatitis and microvesicular steatosis were found in the liver biopsy specimen, consistent with valproate hepatotoxicity.

UR - https://www.scopus.com/pages/publications/0042133150

U2 - 10.1067/S0190-9622(03)00748-5

DO - 10.1067/S0190-9622(03)00748-5

M3 - 文章

C2 - 12894087

AN - SCOPUS:0042133150

SN - 0190-9622

VL - 49

SP - 316

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JO - Journal of the American Academy of Dermatology

JF - Journal of the American Academy of Dermatology

IS - 2

ER -

Fatal sodium valproate-induced hypersensitivity syndrome with lichenoid dermatitis and fulminant hepatitis

Abstract

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