First total synthesis of antrocamphin A and its analogs as anti-inflammatory and anti-platelet aggregation agents

Chia Lin Lee; Chi Huan Huang; Hui Chun Wang; Da Wei Chuang; Ming Jung Wu; Sheng Yang Wang; Tsong Long Hwang; Chin Chung Wu; Yeh Long Chen; Fang Rong Chang; Yang Chang Wu

doi:10.1039/c0ob00616e

First total synthesis of antrocamphin A and its analogs as anti-inflammatory and anti-platelet aggregation agents

Chia Lin Lee, Chi Huan Huang, Hui Chun Wang, Da Wei Chuang, Ming Jung Wu, Sheng Yang Wang, Tsong Long Hwang, Chin Chung Wu, Yeh Long Chen, Fang Rong Chang^*, Yang Chang Wu

^*Corresponding author for this work

School of Traditional Chinese Medicine

Research output: Contribution to journal › Journal Article › peer-review

26 Scopus citations

Abstract

Naturally occurring antrocamphin A (1) is a potent anti-inflammatory compound from the edible fungus Antrodia camphorata (Taiwanofungus camphoratus), whose wild fruiting body is used as a valuable folk medicine in Taiwan. This study is the first total synthesis of antrocamphin A (1) and its analogs. Their inhibition ability on NO release, superoxide anion generation, elastase release and platelet aggregation are reported herein.

Original language	English
Pages (from-to)	70-73
Number of pages	4
Journal	Organic and Biomolecular Chemistry
Volume	9
Issue number	1
DOIs	https://doi.org/10.1039/c0ob00616e
State	Published - 01 01 2011

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abstract = "Naturally occurring antrocamphin A (1) is a potent anti-inflammatory compound from the edible fungus Antrodia camphorata (Taiwanofungus camphoratus), whose wild fruiting body is used as a valuable folk medicine in Taiwan. This study is the first total synthesis of antrocamphin A (1) and its analogs. Their inhibition ability on NO release, superoxide anion generation, elastase release and platelet aggregation are reported herein.",

author = "Lee, {Chia Lin} and Huang, {Chi Huan} and Wang, {Hui Chun} and Chuang, {Da Wei} and Wu, {Ming Jung} and Wang, {Sheng Yang} and Hwang, {Tsong Long} and Wu, {Chin Chung} and Chen, {Yeh Long} and Chang, {Fang Rong} and Wu, {Yang Chang}",

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doi = "10.1039/c0ob00616e",

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AU - Lee, Chia Lin

AU - Huang, Chi Huan

AU - Wang, Hui Chun

AU - Chuang, Da Wei

AU - Wu, Ming Jung

AU - Wang, Sheng Yang

AU - Hwang, Tsong Long

AU - Wu, Chin Chung

AU - Chen, Yeh Long

AU - Chang, Fang Rong

AU - Wu, Yang Chang

PY - 2011/1/1

Y1 - 2011/1/1

N2 - Naturally occurring antrocamphin A (1) is a potent anti-inflammatory compound from the edible fungus Antrodia camphorata (Taiwanofungus camphoratus), whose wild fruiting body is used as a valuable folk medicine in Taiwan. This study is the first total synthesis of antrocamphin A (1) and its analogs. Their inhibition ability on NO release, superoxide anion generation, elastase release and platelet aggregation are reported herein.

AB - Naturally occurring antrocamphin A (1) is a potent anti-inflammatory compound from the edible fungus Antrodia camphorata (Taiwanofungus camphoratus), whose wild fruiting body is used as a valuable folk medicine in Taiwan. This study is the first total synthesis of antrocamphin A (1) and its analogs. Their inhibition ability on NO release, superoxide anion generation, elastase release and platelet aggregation are reported herein.

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U2 - 10.1039/c0ob00616e

DO - 10.1039/c0ob00616e

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SN - 1477-0520

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EP - 73

JO - Organic and Biomolecular Chemistry

JF - Organic and Biomolecular Chemistry

IS - 1

ER -

First total synthesis of antrocamphin A and its analogs as anti-inflammatory and anti-platelet aggregation agents

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