First total synthesis of antrocamphin A and its analogs as anti-inflammatory and anti-platelet aggregation agents

Chia Lin Lee; Chi Huan Huang; Hui Chun Wang; Da Wei Chuang; Ming Jung Wu; Sheng Yang Wang; Tsong Long Hwang; Chin Chung Wu; Yeh Long Chen; Fang Rong Chang; Yang Chang Wu

doi:10.1039/c0ob00616e

First total synthesis of antrocamphin A and its analogs as anti-inflammatory and anti-platelet aggregation agents

Chia Lin Lee
, Chi Huan Huang
, Hui Chun Wang
, Da Wei Chuang
, Ming Jung Wu
, Sheng Yang Wang
, Tsong Long Hwang
, Chin Chung Wu
, Yeh Long Chen
, Fang Rong Chang^*
, Yang Chang Wu

^*Corresponding author for this work

School of Traditional Chinese Medicine

Kaohsiung Medical University
China Medical University Taichung
National Sun Yat-sen University
National Chung Hsing University

Research output: Contribution to journal › Journal Article › peer-review

26 Scopus citations

Abstract

Naturally occurring antrocamphin A (1) is a potent anti-inflammatory compound from the edible fungus Antrodia camphorata (Taiwanofungus camphoratus), whose wild fruiting body is used as a valuable folk medicine in Taiwan. This study is the first total synthesis of antrocamphin A (1) and its analogs. Their inhibition ability on NO release, superoxide anion generation, elastase release and platelet aggregation are reported herein.

Original language	English
Pages (from-to)	70-73
Number of pages	4
Journal	Organic and Biomolecular Chemistry
Volume	9
Issue number	1
DOIs	https://doi.org/10.1039/c0ob00616e
State	Published - 01 01 2011

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abstract = "Naturally occurring antrocamphin A (1) is a potent anti-inflammatory compound from the edible fungus Antrodia camphorata (Taiwanofungus camphoratus), whose wild fruiting body is used as a valuable folk medicine in Taiwan. This study is the first total synthesis of antrocamphin A (1) and its analogs. Their inhibition ability on NO release, superoxide anion generation, elastase release and platelet aggregation are reported herein.",

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year = "2011",

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doi = "10.1039/c0ob00616e",

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AU - Lee, Chia Lin

AU - Huang, Chi Huan

AU - Wang, Hui Chun

AU - Chuang, Da Wei

AU - Wu, Ming Jung

AU - Wang, Sheng Yang

AU - Hwang, Tsong Long

AU - Wu, Chin Chung

AU - Chen, Yeh Long

AU - Chang, Fang Rong

AU - Wu, Yang Chang

PY - 2011/1/1

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N2 - Naturally occurring antrocamphin A (1) is a potent anti-inflammatory compound from the edible fungus Antrodia camphorata (Taiwanofungus camphoratus), whose wild fruiting body is used as a valuable folk medicine in Taiwan. This study is the first total synthesis of antrocamphin A (1) and its analogs. Their inhibition ability on NO release, superoxide anion generation, elastase release and platelet aggregation are reported herein.

AB - Naturally occurring antrocamphin A (1) is a potent anti-inflammatory compound from the edible fungus Antrodia camphorata (Taiwanofungus camphoratus), whose wild fruiting body is used as a valuable folk medicine in Taiwan. This study is the first total synthesis of antrocamphin A (1) and its analogs. Their inhibition ability on NO release, superoxide anion generation, elastase release and platelet aggregation are reported herein.

UR - https://www.scopus.com/pages/publications/78650100657

U2 - 10.1039/c0ob00616e

DO - 10.1039/c0ob00616e

M3 - 文章

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SN - 1477-0520

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EP - 73

JO - Organic and Biomolecular Chemistry

JF - Organic and Biomolecular Chemistry

IS - 1

ER -

First total synthesis of antrocamphin A and its analogs as anti-inflammatory and anti-platelet aggregation agents

Abstract

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