Flexibilins A-C, new cembrane-type diterpenoids from the Formosan soft coral, Sinularia flexibilis

Li Chung Hu; Jui Hsin Su; Michael Yen Nan Chiang; Mei Chin Lu; Tsong Long Hwang; Yung Husan Chen; Wan Ping Hu; Nai Cheng Lin; Wei Hsien Wang; Lee Shing Fang; Yueh Hsiung Kuo; Ping Jyun Sung

doi:10.3390/md11061999

Flexibilins A-C, new cembrane-type diterpenoids from the Formosan soft coral, Sinularia flexibilis

Li Chung Hu, Jui Hsin Su, Michael Yen Nan Chiang, Mei Chin Lu, Tsong Long Hwang, Yung Husan Chen, Wan Ping Hu, Nai Cheng Lin, Wei Hsien Wang, Lee Shing Fang, Yueh Hsiung Kuo^*, Ping Jyun Sung

^*Corresponding author for this work

School of Traditional Chinese Medicine

Research output: Contribution to journal › Journal Article › peer-review

20 Scopus citations

Abstract

Three new cembrane-type diterpenoids, flexibilins A-C (1-3), along with a known cembrane, (-)-sandensolide (4), were isolated from the soft coral, Sinularia flexibilis. The structures of cembranes 1-4 were elucidated by spectroscopic methods. The structure of 4, including its absolute stereochemistry, was further confirmed by single-crystal X-ray diffraction analysis. Cembrane 2 displayed a moderate inhibitory effect on the release of elastase by human neutrophils.

Original language	English
Pages (from-to)	1999-2012
Number of pages	14
Journal	Marine Drugs
Volume	11
Issue number	6
DOIs	https://doi.org/10.3390/md11061999
State	Published - 06 2013

Keywords

Cembrane
Diterpenoid
Elastase
Sinularia flexibilis

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10.3390/md11061999

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title = "Flexibilins A-C, new cembrane-type diterpenoids from the Formosan soft coral, Sinularia flexibilis",

abstract = "Three new cembrane-type diterpenoids, flexibilins A-C (1-3), along with a known cembrane, (-)-sandensolide (4), were isolated from the soft coral, Sinularia flexibilis. The structures of cembranes 1-4 were elucidated by spectroscopic methods. The structure of 4, including its absolute stereochemistry, was further confirmed by single-crystal X-ray diffraction analysis. Cembrane 2 displayed a moderate inhibitory effect on the release of elastase by human neutrophils.",

keywords = "Cembrane, Diterpenoid, Elastase, Sinularia flexibilis",

author = "Hu, {Li Chung} and Su, {Jui Hsin} and Chiang, {Michael Yen Nan} and Lu, {Mei Chin} and Hwang, {Tsong Long} and Chen, {Yung Husan} and Hu, {Wan Ping} and Lin, {Nai Cheng} and Wang, {Wei Hsien} and Fang, {Lee Shing} and Kuo, {Yueh Hsiung} and Sung, {Ping Jyun}",

year = "2013",

month = jun,

doi = "10.3390/md11061999",

language = "英语",

volume = "11",

pages = "1999--2012",

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T1 - Flexibilins A-C, new cembrane-type diterpenoids from the Formosan soft coral, Sinularia flexibilis

AU - Hu, Li Chung

AU - Su, Jui Hsin

AU - Chiang, Michael Yen Nan

AU - Lu, Mei Chin

AU - Hwang, Tsong Long

AU - Chen, Yung Husan

AU - Hu, Wan Ping

AU - Lin, Nai Cheng

AU - Wang, Wei Hsien

AU - Fang, Lee Shing

AU - Kuo, Yueh Hsiung

AU - Sung, Ping Jyun

PY - 2013/6

Y1 - 2013/6

N2 - Three new cembrane-type diterpenoids, flexibilins A-C (1-3), along with a known cembrane, (-)-sandensolide (4), were isolated from the soft coral, Sinularia flexibilis. The structures of cembranes 1-4 were elucidated by spectroscopic methods. The structure of 4, including its absolute stereochemistry, was further confirmed by single-crystal X-ray diffraction analysis. Cembrane 2 displayed a moderate inhibitory effect on the release of elastase by human neutrophils.

AB - Three new cembrane-type diterpenoids, flexibilins A-C (1-3), along with a known cembrane, (-)-sandensolide (4), were isolated from the soft coral, Sinularia flexibilis. The structures of cembranes 1-4 were elucidated by spectroscopic methods. The structure of 4, including its absolute stereochemistry, was further confirmed by single-crystal X-ray diffraction analysis. Cembrane 2 displayed a moderate inhibitory effect on the release of elastase by human neutrophils.

KW - Cembrane

KW - Diterpenoid

KW - Elastase

KW - Sinularia flexibilis

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U2 - 10.3390/md11061999

DO - 10.3390/md11061999

M3 - 文章

C2 - 23752355

AN - SCOPUS:84879473865

SN - 1660-3397

VL - 11

SP - 1999

EP - 2012

JO - Marine Drugs

JF - Marine Drugs

IS - 6

ER -

Flexibilins A-C, new cembrane-type diterpenoids from the Formosan soft coral, Sinularia flexibilis

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Keywords

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