Flexibilins A-C, new cembrane-type diterpenoids from the Formosan soft coral, Sinularia flexibilis

Li Chung Hu; Jui Hsin Su; Michael Yen Nan Chiang; Mei Chin Lu; Tsong Long Hwang; Yung Husan Chen; Wan Ping Hu; Nai Cheng Lin; Wei Hsien Wang; Lee Shing Fang; Yueh Hsiung Kuo; Ping Jyun Sung

doi:10.3390/md11061999

Flexibilins A-C, new cembrane-type diterpenoids from the Formosan soft coral, Sinularia flexibilis

Li Chung Hu
, Jui Hsin Su
, Michael Yen Nan Chiang
, Mei Chin Lu
, Tsong Long Hwang
, Yung Husan Chen
, Wan Ping Hu
, Nai Cheng Lin
, Wei Hsien Wang
, Lee Shing Fang
, Yueh Hsiung Kuo^*
, Ping Jyun Sung

^*Corresponding author for this work

School of Traditional Chinese Medicine

National Dong Hwa University
National Museum of Marine Biology and Aquarium, Taiwan
National Sun Yat-sen University
Kaohsiung Medical University
Cheng Shiu University Taiwan
China Medical University Taichung

Research output: Contribution to journal › Journal Article › peer-review

23 Scopus citations

Abstract

Three new cembrane-type diterpenoids, flexibilins A-C (1-3), along with a known cembrane, (-)-sandensolide (4), were isolated from the soft coral, Sinularia flexibilis. The structures of cembranes 1-4 were elucidated by spectroscopic methods. The structure of 4, including its absolute stereochemistry, was further confirmed by single-crystal X-ray diffraction analysis. Cembrane 2 displayed a moderate inhibitory effect on the release of elastase by human neutrophils.

Original language	English
Pages (from-to)	1999-2012
Number of pages	14
Journal	Marine Drugs
Volume	11
Issue number	6
DOIs	https://doi.org/10.3390/md11061999
State	Published - 06 2013

Keywords

Cembrane
Diterpenoid
Elastase
Sinularia flexibilis

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10.3390/md11061999

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title = "Flexibilins A-C, new cembrane-type diterpenoids from the Formosan soft coral, Sinularia flexibilis",

abstract = "Three new cembrane-type diterpenoids, flexibilins A-C (1-3), along with a known cembrane, (-)-sandensolide (4), were isolated from the soft coral, Sinularia flexibilis. The structures of cembranes 1-4 were elucidated by spectroscopic methods. The structure of 4, including its absolute stereochemistry, was further confirmed by single-crystal X-ray diffraction analysis. Cembrane 2 displayed a moderate inhibitory effect on the release of elastase by human neutrophils.",

keywords = "Cembrane, Diterpenoid, Elastase, Sinularia flexibilis",

author = "Hu, \{Li Chung\} and Su, \{Jui Hsin\} and Chiang, \{Michael Yen Nan\} and Lu, \{Mei Chin\} and Hwang, \{Tsong Long\} and Chen, \{Yung Husan\} and Hu, \{Wan Ping\} and Lin, \{Nai Cheng\} and Wang, \{Wei Hsien\} and Fang, \{Lee Shing\} and Kuo, \{Yueh Hsiung\} and Sung, \{Ping Jyun\}",

year = "2013",

month = jun,

doi = "10.3390/md11061999",

language = "英语",

volume = "11",

pages = "1999--2012",

journal = "Marine Drugs",

issn = "1660-3397",

publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",

number = "6",

}

TY - JOUR

T1 - Flexibilins A-C, new cembrane-type diterpenoids from the Formosan soft coral, Sinularia flexibilis

AU - Hu, Li Chung

AU - Su, Jui Hsin

AU - Chiang, Michael Yen Nan

AU - Lu, Mei Chin

AU - Hwang, Tsong Long

AU - Chen, Yung Husan

AU - Hu, Wan Ping

AU - Lin, Nai Cheng

AU - Wang, Wei Hsien

AU - Fang, Lee Shing

AU - Kuo, Yueh Hsiung

AU - Sung, Ping Jyun

PY - 2013/6

Y1 - 2013/6

N2 - Three new cembrane-type diterpenoids, flexibilins A-C (1-3), along with a known cembrane, (-)-sandensolide (4), were isolated from the soft coral, Sinularia flexibilis. The structures of cembranes 1-4 were elucidated by spectroscopic methods. The structure of 4, including its absolute stereochemistry, was further confirmed by single-crystal X-ray diffraction analysis. Cembrane 2 displayed a moderate inhibitory effect on the release of elastase by human neutrophils.

AB - Three new cembrane-type diterpenoids, flexibilins A-C (1-3), along with a known cembrane, (-)-sandensolide (4), were isolated from the soft coral, Sinularia flexibilis. The structures of cembranes 1-4 were elucidated by spectroscopic methods. The structure of 4, including its absolute stereochemistry, was further confirmed by single-crystal X-ray diffraction analysis. Cembrane 2 displayed a moderate inhibitory effect on the release of elastase by human neutrophils.

KW - Cembrane

KW - Diterpenoid

KW - Elastase

KW - Sinularia flexibilis

UR - https://www.scopus.com/pages/publications/84879473865

U2 - 10.3390/md11061999

DO - 10.3390/md11061999

M3 - 文章

C2 - 23752355

AN - SCOPUS:84879473865

SN - 1660-3397

VL - 11

SP - 1999

EP - 2012

JO - Marine Drugs

JF - Marine Drugs

IS - 6

ER -

Flexibilins A-C, new cembrane-type diterpenoids from the Formosan soft coral, Sinularia flexibilis

Abstract

Keywords

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