Flexible and Robust Piezoelectric Chitosan Films with Enhanced Bioactivity

Srishti Chakraborty; Souvik Debnath; Kailas Mahipal Malappuram; Sampath Parasuram; Huan Tsung Chang; Kaushik Chatterjee; Amit Nain

doi:10.1021/acs.biomac.4c01464

Flexible and Robust Piezoelectric Chitosan Films with Enhanced Bioactivity

Srishti Chakraborty, Souvik Debnath, Kailas Mahipal Malappuram, Sampath Parasuram, Huan Tsung Chang, Kaushik Chatterjee^*, Amit Nain^*

^*Corresponding author for this work

Department of Biomedical Sciences (Master's Program in Clinical Trials Assessment)

Research output: Contribution to journal › Journal Article › peer-review

3 Scopus citations

Abstract

Chitosan (CHT) is a known piezoelectric biomacromolecule; however, its usage is limited due to rapid degradation in an aqueous system. Herein, we prepared CHT film via a solvent casting method and cross-linked in an alkaline solution. Sodium hydroxide facilitated deprotonation, leading to increased intramolecular hydrogen bonding and mechanical properties. The CHT film remained intact for 30 days in aqueous environments. A systematic study revealed a gradual increase in the output voltage from 0.9 to 1.8 V under external force (1-16 N). In addition, the CHT film showed remarkable antibacterial and anti-inflammatory activities under ultrasound stimulation and inhibition of inflammatory cytokines. The CHT films also displayed enhanced cellular proliferation and ∼5-fold faster migration of NIH3T3 cells under US stimulation. Overall, this work presents a robust, biocompatible, and wearable CHT device that can transform biomechanical energy into electrical pulses for the modulation of cell fate processes and other bioactivities.

Original language	English
Pages (from-to)	1128-1140
Number of pages	13
Journal	Biomacromolecules
Volume	26
Issue number	2
Early online date	13 01 2025
DOIs	https://doi.org/10.1021/acs.biomac.4c01464
State	Published - 10 02 2025

Bibliographical note

Publisher Copyright:
© 2025 American Chemical Society.

Keywords

Chitosan/chemistry
Mice
Animals
NIH 3T3 Cells
Anti-Bacterial Agents/pharmacology
Biocompatible Materials/chemistry
Cell Proliferation/drug effects
Anti-Inflammatory Agents/pharmacology
Cell Movement/drug effects

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10.1021/acs.biomac.4c01464

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title = "Flexible and Robust Piezoelectric Chitosan Films with Enhanced Bioactivity",

abstract = "Chitosan (CHT) is a known piezoelectric biomacromolecule; however, its usage is limited due to rapid degradation in an aqueous system. Herein, we prepared CHT film via a solvent casting method and cross-linked in an alkaline solution. Sodium hydroxide facilitated deprotonation, leading to increased intramolecular hydrogen bonding and mechanical properties. The CHT film remained intact for 30 days in aqueous environments. A systematic study revealed a gradual increase in the output voltage from 0.9 to 1.8 V under external force (1-16 N). In addition, the CHT film showed remarkable antibacterial and anti-inflammatory activities under ultrasound stimulation and inhibition of inflammatory cytokines. The CHT films also displayed enhanced cellular proliferation and ∼5-fold faster migration of NIH3T3 cells under US stimulation. Overall, this work presents a robust, biocompatible, and wearable CHT device that can transform biomechanical energy into electrical pulses for the modulation of cell fate processes and other bioactivities.",

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author = "Srishti Chakraborty and Souvik Debnath and \{Mahipal Malappuram\}, Kailas and Sampath Parasuram and Chang, \{Huan Tsung\} and Kaushik Chatterjee and Amit Nain",

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doi = "10.1021/acs.biomac.4c01464",

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AU - Chakraborty, Srishti

AU - Debnath, Souvik

AU - Mahipal Malappuram, Kailas

AU - Parasuram, Sampath

AU - Chang, Huan Tsung

AU - Chatterjee, Kaushik

AU - Nain, Amit

PY - 2025/2/10

Y1 - 2025/2/10

N2 - Chitosan (CHT) is a known piezoelectric biomacromolecule; however, its usage is limited due to rapid degradation in an aqueous system. Herein, we prepared CHT film via a solvent casting method and cross-linked in an alkaline solution. Sodium hydroxide facilitated deprotonation, leading to increased intramolecular hydrogen bonding and mechanical properties. The CHT film remained intact for 30 days in aqueous environments. A systematic study revealed a gradual increase in the output voltage from 0.9 to 1.8 V under external force (1-16 N). In addition, the CHT film showed remarkable antibacterial and anti-inflammatory activities under ultrasound stimulation and inhibition of inflammatory cytokines. The CHT films also displayed enhanced cellular proliferation and ∼5-fold faster migration of NIH3T3 cells under US stimulation. Overall, this work presents a robust, biocompatible, and wearable CHT device that can transform biomechanical energy into electrical pulses for the modulation of cell fate processes and other bioactivities.

AB - Chitosan (CHT) is a known piezoelectric biomacromolecule; however, its usage is limited due to rapid degradation in an aqueous system. Herein, we prepared CHT film via a solvent casting method and cross-linked in an alkaline solution. Sodium hydroxide facilitated deprotonation, leading to increased intramolecular hydrogen bonding and mechanical properties. The CHT film remained intact for 30 days in aqueous environments. A systematic study revealed a gradual increase in the output voltage from 0.9 to 1.8 V under external force (1-16 N). In addition, the CHT film showed remarkable antibacterial and anti-inflammatory activities under ultrasound stimulation and inhibition of inflammatory cytokines. The CHT films also displayed enhanced cellular proliferation and ∼5-fold faster migration of NIH3T3 cells under US stimulation. Overall, this work presents a robust, biocompatible, and wearable CHT device that can transform biomechanical energy into electrical pulses for the modulation of cell fate processes and other bioactivities.

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KW - Mice

KW - Animals

KW - NIH 3T3 Cells

KW - Anti-Bacterial Agents/pharmacology

KW - Biocompatible Materials/chemistry

KW - Cell Proliferation/drug effects

KW - Anti-Inflammatory Agents/pharmacology

KW - Cell Movement/drug effects

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U2 - 10.1021/acs.biomac.4c01464

DO - 10.1021/acs.biomac.4c01464

M3 - 文章

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AN - SCOPUS:85215660143

SN - 1525-7797

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JO - Biomacromolecules

JF - Biomacromolecules

IS - 2

ER -

Flexible and Robust Piezoelectric Chitosan Films with Enhanced Bioactivity

Abstract

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