Fluorescent gold nanodots based sensor array for proteins discrimination

Zhiqin Yuan; Yi Du; Yu Ting Tseng; Meihua Peng; Na Cai; Yan He; Huan Tsung Chang; Edward S. Yeung

doi:10.1021/ac5045302

Fluorescent gold nanodots based sensor array for proteins discrimination

Zhiqin Yuan
, Yi Du
, Yu Ting Tseng
, Meihua Peng
, Na Cai
, Yan He
, Huan Tsung Chang^*
, Edward S. Yeung

^*Corresponding author for this work

Research output: Contribution to journal › Journal Article › peer-review

119 Scopus citations

Abstract

A series of dual-ligand cofunctionalized fluorescent gold nanodots with similar fluorescence and diverse surface properties has been designed and synthesized to build a protein sensing array. Using this chemical nose/tongue strategy, fluorescence response patterns can be obtained on the array and identified via linear discriminant analysis (LDA). Eight proteins have been well distinguished at low concentration (A₂₈₀ = 0.005) based on this sensor array. The practicability of this sensor array was further validated by high accuracy (100%) examination of 48 unknown protein samples.

Original language	English
Pages (from-to)	4253-4259
Number of pages	7
Journal	Analytical Chemistry
Volume	87
Issue number	8
DOIs	https://doi.org/10.1021/ac5045302
State	Published - 21 04 2015
Externally published	Yes

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© 2015 American Chemical Society.

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title = "Fluorescent gold nanodots based sensor array for proteins discrimination",

abstract = "A series of dual-ligand cofunctionalized fluorescent gold nanodots with similar fluorescence and diverse surface properties has been designed and synthesized to build a protein sensing array. Using this chemical nose/tongue strategy, fluorescence response patterns can be obtained on the array and identified via linear discriminant analysis (LDA). Eight proteins have been well distinguished at low concentration (A280 = 0.005) based on this sensor array. The practicability of this sensor array was further validated by high accuracy (100\%) examination of 48 unknown protein samples.",

author = "Zhiqin Yuan and Yi Du and Tseng, \{Yu Ting\} and Meihua Peng and Na Cai and Yan He and Chang, \{Huan Tsung\} and Yeung, \{Edward S.\}",

note = "Publisher Copyright: {\textcopyright} 2015 American Chemical Society.",

year = "2015",

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doi = "10.1021/ac5045302",

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T1 - Fluorescent gold nanodots based sensor array for proteins discrimination

AU - Yuan, Zhiqin

AU - Du, Yi

AU - Tseng, Yu Ting

AU - Peng, Meihua

AU - Cai, Na

AU - He, Yan

AU - Chang, Huan Tsung

AU - Yeung, Edward S.

PY - 2015/4/21

Y1 - 2015/4/21

N2 - A series of dual-ligand cofunctionalized fluorescent gold nanodots with similar fluorescence and diverse surface properties has been designed and synthesized to build a protein sensing array. Using this chemical nose/tongue strategy, fluorescence response patterns can be obtained on the array and identified via linear discriminant analysis (LDA). Eight proteins have been well distinguished at low concentration (A280 = 0.005) based on this sensor array. The practicability of this sensor array was further validated by high accuracy (100%) examination of 48 unknown protein samples.

AB - A series of dual-ligand cofunctionalized fluorescent gold nanodots with similar fluorescence and diverse surface properties has been designed and synthesized to build a protein sensing array. Using this chemical nose/tongue strategy, fluorescence response patterns can be obtained on the array and identified via linear discriminant analysis (LDA). Eight proteins have been well distinguished at low concentration (A280 = 0.005) based on this sensor array. The practicability of this sensor array was further validated by high accuracy (100%) examination of 48 unknown protein samples.

UR - https://www.scopus.com/pages/publications/84928473641

U2 - 10.1021/ac5045302

DO - 10.1021/ac5045302

M3 - 文章

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SP - 4253

EP - 4259

JO - Analytical Chemistry

JF - Analytical Chemistry

IS - 8

ER -

Fluorescent gold nanodots based sensor array for proteins discrimination

Abstract

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