TY - GEN
T1 - Formation of 12∗Mapping using mixed-effects model
AU - Huang, Hsuan Ming
PY - 2017/10/16
Y1 - 2017/10/16
N2 - Using ultrashort echo time (UTE) magnetic resonance imaging (MR1), T2∗ can be measured and used to evaluate cartilage degradation. In general, high-quality MRI is required for accurate T2∗ measurement. However, such high-quality MRI requires long scan times which make the clinical utility of T2∗ measurement infeasible. Thus, a method that can produce satisfactory T2∗ maps within reasonable scan times (i.e. limited data) is required. Non-linear mixed-effects model (NLME) is a powerful tool for analyzing incomplete longitudinal data. Since NLME contains both fixed and random effects, it is preferred over more traditional methods. The aim of this study is to investigate whether T2∗ map can be generated using INLME. The simulation results show that NLME is a feasible method for T2∗ measurement. Moreover, NLME can improve the accuracy and precision of parameter estimates compared to the traditional non-linear least square fit.
AB - Using ultrashort echo time (UTE) magnetic resonance imaging (MR1), T2∗ can be measured and used to evaluate cartilage degradation. In general, high-quality MRI is required for accurate T2∗ measurement. However, such high-quality MRI requires long scan times which make the clinical utility of T2∗ measurement infeasible. Thus, a method that can produce satisfactory T2∗ maps within reasonable scan times (i.e. limited data) is required. Non-linear mixed-effects model (NLME) is a powerful tool for analyzing incomplete longitudinal data. Since NLME contains both fixed and random effects, it is preferred over more traditional methods. The aim of this study is to investigate whether T2∗ map can be generated using INLME. The simulation results show that NLME is a feasible method for T2∗ measurement. Moreover, NLME can improve the accuracy and precision of parameter estimates compared to the traditional non-linear least square fit.
UR - http://www.scopus.com/inward/record.url?scp=85041498982&partnerID=8YFLogxK
U2 - 10.1109/NSSMIC.2016.8069541
DO - 10.1109/NSSMIC.2016.8069541
M3 - 会议稿件
AN - SCOPUS:85041498982
T3 - 2016 IEEE Nuclear Science Symposium, Medical Imaging Conference and Room-Temperature Semiconductor Detector Workshop, NSS/MIC/RTSD 2016
BT - 2016 IEEE Nuclear Science Symposium, Medical Imaging Conference and Room-Temperature Semiconductor Detector Workshop, NSS/MIC/RTSD 2016
PB - Institute of Electrical and Electronics Engineers Inc.
T2 - 2016 IEEE Nuclear Science Symposium, Medical Imaging Conference and Room-Temperature Semiconductor Detector Workshop, NSS/MIC/RTSD 2016
Y2 - 29 October 2016 through 6 November 2016
ER -