Four new briarane diterpenoids from the gorgonian coral Junceella fragilis

Ya Ching Shen; Yu Hui Chen; Tsong Long Hwang; Jih Hwa Guh; Ashraf Taha Khalil

doi:10.1002/hlca.200790141

Four new briarane diterpenoids from the gorgonian coral Junceella fragilis

Ya Ching Shen^*, Yu Hui Chen, Tsong Long Hwang, Jih Hwa Guh, Ashraf Taha Khalil

^*Corresponding author for this work

School of Traditional Chinese Medicine

Research output: Contribution to journal › Journal Article › peer-review

39 Scopus citations

Abstract

Chemical investigation of the gorgonian coral Junceella fragilis, collected by scuba diving in Taiwan, resulted in the isolation of four new briarane-type diterpenoids, frajunolides A-D (1-4), along with three known briaranes. Their structures were elucidated on the basis of spectroscopic studies, especially 1- and 2D-NMR as well as HR-MS experiments. The inhibitory effect of all isolated metabolites towards superoxide-anion generation and elastase release by human neutrophils in response to formylmethionyl-leucyl-phenylalanine/ dihydrocytochalasin B (FMLP/CB) was evaluated.

Original language	English
Pages (from-to)	1391-1398
Number of pages	8
Journal	Helvetica Chimica Acta
Volume	90
Issue number	7
DOIs	https://doi.org/10.1002/hlca.200790141
State	Published - 2007

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AU - Chen, Yu Hui

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AU - Guh, Jih Hwa

AU - Khalil, Ashraf Taha

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AB - Chemical investigation of the gorgonian coral Junceella fragilis, collected by scuba diving in Taiwan, resulted in the isolation of four new briarane-type diterpenoids, frajunolides A-D (1-4), along with three known briaranes. Their structures were elucidated on the basis of spectroscopic studies, especially 1- and 2D-NMR as well as HR-MS experiments. The inhibitory effect of all isolated metabolites towards superoxide-anion generation and elastase release by human neutrophils in response to formylmethionyl-leucyl-phenylalanine/ dihydrocytochalasin B (FMLP/CB) was evaluated.

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Four new briarane diterpenoids from the gorgonian coral Junceella fragilis

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