Four new briarane diterpenoids from the gorgonian coral Junceella fragilis

Ya Ching Shen; Yu Hui Chen; Tsong Long Hwang; Jih Hwa Guh; Ashraf Taha Khalil

doi:10.1002/hlca.200790141

Four new briarane diterpenoids from the gorgonian coral Junceella fragilis

Ya Ching Shen^*
, Yu Hui Chen
, Tsong Long Hwang
, Jih Hwa Guh
, Ashraf Taha Khalil

^*Corresponding author for this work

School of Traditional Chinese Medicine

Research output: Contribution to journal › Journal Article › peer-review

41 Scopus citations

Abstract

Chemical investigation of the gorgonian coral Junceella fragilis, collected by scuba diving in Taiwan, resulted in the isolation of four new briarane-type diterpenoids, frajunolides A-D (1-4), along with three known briaranes. Their structures were elucidated on the basis of spectroscopic studies, especially 1- and 2D-NMR as well as HR-MS experiments. The inhibitory effect of all isolated metabolites towards superoxide-anion generation and elastase release by human neutrophils in response to formylmethionyl-leucyl-phenylalanine/ dihydrocytochalasin B (FMLP/CB) was evaluated.

Original language	English
Pages (from-to)	1391-1398
Number of pages	8
Journal	Helvetica Chimica Acta
Volume	90
Issue number	7
DOIs	https://doi.org/10.1002/hlca.200790141
State	Published - 2007

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abstract = "Chemical investigation of the gorgonian coral Junceella fragilis, collected by scuba diving in Taiwan, resulted in the isolation of four new briarane-type diterpenoids, frajunolides A-D (1-4), along with three known briaranes. Their structures were elucidated on the basis of spectroscopic studies, especially 1- and 2D-NMR as well as HR-MS experiments. The inhibitory effect of all isolated metabolites towards superoxide-anion generation and elastase release by human neutrophils in response to formylmethionyl-leucyl-phenylalanine/ dihydrocytochalasin B (FMLP/CB) was evaluated.",

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AU - Shen, Ya Ching

AU - Chen, Yu Hui

AU - Hwang, Tsong Long

AU - Guh, Jih Hwa

AU - Khalil, Ashraf Taha

PY - 2007

Y1 - 2007

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AB - Chemical investigation of the gorgonian coral Junceella fragilis, collected by scuba diving in Taiwan, resulted in the isolation of four new briarane-type diterpenoids, frajunolides A-D (1-4), along with three known briaranes. Their structures were elucidated on the basis of spectroscopic studies, especially 1- and 2D-NMR as well as HR-MS experiments. The inhibitory effect of all isolated metabolites towards superoxide-anion generation and elastase release by human neutrophils in response to formylmethionyl-leucyl-phenylalanine/ dihydrocytochalasin B (FMLP/CB) was evaluated.

UR - https://www.scopus.com/pages/publications/34547571549

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DO - 10.1002/hlca.200790141

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JO - Helvetica Chimica Acta

JF - Helvetica Chimica Acta

IS - 7

ER -

Four new briarane diterpenoids from the gorgonian coral Junceella fragilis

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