FPGA-Controlled High-Power Driving Design for High Intensity Focused Ultrasound Application

Focused ultrasound (FUS) therapy has gained significant attention due to its non-invasive treatment approach in recent years, and become one of the promising clinical treatment tools. In order to meet the future portable needs, the driving circuit must be capable of providing high-frequency and high-power outputs to generate sufficient acoustic pressure for focused ultrasound energy delivery to overcome obstacles such as transcranial application. In this study, we have designed a four-channel FUS driving system for transcranial application. The system is controlled by an FPGA (Field-Programmable Gate Array) that manages signals received from a PC. The system comprises four-channel and linearly controllable high-voltage amplification through a combination of a DAC (Digital-to-Analog Converter) and phase delay units, analog sinusoidal signals with controlled phase differences are generated from the digital input signals. These driving signal routed through the driving circuit to the concaved diced transducer, achieved the acoustic pressure at the focal point up to 3 MPa, thereby meeting the clinical requirements for transcranial FUS therapy.