TY - JOUR
T1 - Fractioned dose regimen of sunitinib for patients with gastrointestinal stromal tumor
T2 - A pharmacokinetic and treatment efficacy study
AU - Chen, Yen Yang
AU - Yeh, Chun Nan
AU - Cheng, Chi Tung
AU - Wu, Chao En
AU - Chiang, Kun Chun
AU - Chen, Tsung Wen
AU - Wang, Chih Chi
AU - Chen, Jen Shi
AU - Yeh, Ta Sen
N1 - Publisher Copyright:
© 2014 Neoplasia Press, Inc.
PY - 2014
Y1 - 2014
N2 - AIM: Sunitinib has shown benefit in patients with imatinib (IM)–resistant gastrointestinal stromal tumor (GIST). However, its advantages are somewhat diminished because of associated toxicities. Herein, we clarify the efficacy and safety of fractioned dose regimen of sunitinib by a pharmacokinetic and efficacy study. MATERIALS AND METHODS: Between 2001 andMarch 2013, a total of 214 patients withmetastaticGIST was treated at ChangGungMemorialHospital.Among them, 55 (11.6%) patients who received sunitinib were investigated. One group of patients was administered with standard dose of once-daily sunitinib (standard dose group) and the other group was administered with standard total daily dose of sunitinib in fractioned doses (fractioned dose group). RESULTS: Thirty-two male and 23 female patientswith amedian age of 55 years received sunitinib. The median duration of sunitinib administration was 9.2 months. The clinical benefit was 65.2%. Themean peak blood level of sunitinib in patients with fractioned doses was significantly lower than that in those with once-daily dose (83.4 vs 50.1 ng/ml, P =.01). The rates of adverse effects of hand-foot syndrome, mucositis, and yellow skin were significantly decreased by fractioned doses of sunitinib. However, the progression-free and overall survival did not differ between patients with different treatment regimens. CONCLUSION: The fractioned dose regimen of sunitinib appears to be a safe and effective treatment for patients with IM-resistant/intolerant GISTs. Significantly decreased toxicity of this regimen could be explained by significantly lower peak sunitinib blood level. However, the treatment efficacy is not reduced by this regimen.
AB - AIM: Sunitinib has shown benefit in patients with imatinib (IM)–resistant gastrointestinal stromal tumor (GIST). However, its advantages are somewhat diminished because of associated toxicities. Herein, we clarify the efficacy and safety of fractioned dose regimen of sunitinib by a pharmacokinetic and efficacy study. MATERIALS AND METHODS: Between 2001 andMarch 2013, a total of 214 patients withmetastaticGIST was treated at ChangGungMemorialHospital.Among them, 55 (11.6%) patients who received sunitinib were investigated. One group of patients was administered with standard dose of once-daily sunitinib (standard dose group) and the other group was administered with standard total daily dose of sunitinib in fractioned doses (fractioned dose group). RESULTS: Thirty-two male and 23 female patientswith amedian age of 55 years received sunitinib. The median duration of sunitinib administration was 9.2 months. The clinical benefit was 65.2%. Themean peak blood level of sunitinib in patients with fractioned doses was significantly lower than that in those with once-daily dose (83.4 vs 50.1 ng/ml, P =.01). The rates of adverse effects of hand-foot syndrome, mucositis, and yellow skin were significantly decreased by fractioned doses of sunitinib. However, the progression-free and overall survival did not differ between patients with different treatment regimens. CONCLUSION: The fractioned dose regimen of sunitinib appears to be a safe and effective treatment for patients with IM-resistant/intolerant GISTs. Significantly decreased toxicity of this regimen could be explained by significantly lower peak sunitinib blood level. However, the treatment efficacy is not reduced by this regimen.
UR - http://www.scopus.com/inward/record.url?scp=84915806084&partnerID=8YFLogxK
U2 - 10.1016/j.tranon.2014.08.004
DO - 10.1016/j.tranon.2014.08.004
M3 - 文章
AN - SCOPUS:84915806084
SN - 1936-5233
VL - 7
SP - 620
EP - 625
JO - Translational Oncology
JF - Translational Oncology
IS - 5
ER -