Frajunolides L-O, four new 8-hydroxybriarane diterpenoids from the Gorgonian Junceella fragilis

Chia Ching Liaw; Yao Haur Kuo; Yun Sheng Lin; Tsong Long Hwang; Ya Ching Shen

doi:10.3390/md9091477

Frajunolides L-O, four new 8-hydroxybriarane diterpenoids from the Gorgonian Junceella fragilis

Chia Ching Liaw, Yao Haur Kuo, Yun Sheng Lin, Tsong Long Hwang, Ya Ching Shen^*

^*Corresponding author for this work

School of Traditional Chinese Medicine

Research output: Contribution to journal › Journal Article › peer-review

19 Scopus citations

Abstract

Four new 8-hydroxybriarane diterpenoids, frajunolides L-O (1-4), were isolated from the Taiwanese gorgonian Junceella fragilis. The structures of compounds 1-4 were elucidated based on spectroscopic analysis, especially 2D NMR (¹H-¹H COSY, HSQC, HMBC and NOESY) and HRMS. Compounds 1 and 4 showed weak anti-inflammatory activity as tested by superoxide anion generation and elastase release by human neutrophil in response to fMLP/CB. Compound 3 showed selective inhibition on elastase release in vitro.

Original language	English
Pages (from-to)	1477-1486
Number of pages	10
Journal	Marine Drugs
Volume	9
Issue number	9
DOIs	https://doi.org/10.3390/md9091477
State	Published - 09 2011

Keywords

8-hydroxybriarane
Anti-inflammatory activities
Frajunolides
Junceella fragilis

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title = "Frajunolides L-O, four new 8-hydroxybriarane diterpenoids from the Gorgonian Junceella fragilis",

abstract = "Four new 8-hydroxybriarane diterpenoids, frajunolides L-O (1-4), were isolated from the Taiwanese gorgonian Junceella fragilis. The structures of compounds 1-4 were elucidated based on spectroscopic analysis, especially 2D NMR (1H-1H COSY, HSQC, HMBC and NOESY) and HRMS. Compounds 1 and 4 showed weak anti-inflammatory activity as tested by superoxide anion generation and elastase release by human neutrophil in response to fMLP/CB. Compound 3 showed selective inhibition on elastase release in vitro.",

keywords = "8-hydroxybriarane, Anti-inflammatory activities, Frajunolides, Junceella fragilis",

author = "Liaw, {Chia Ching} and Kuo, {Yao Haur} and Lin, {Yun Sheng} and Hwang, {Tsong Long} and Shen, {Ya Ching}",

year = "2011",

month = sep,

doi = "10.3390/md9091477",

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T1 - Frajunolides L-O, four new 8-hydroxybriarane diterpenoids from the Gorgonian Junceella fragilis

AU - Liaw, Chia Ching

AU - Kuo, Yao Haur

AU - Lin, Yun Sheng

AU - Hwang, Tsong Long

AU - Shen, Ya Ching

PY - 2011/9

Y1 - 2011/9

N2 - Four new 8-hydroxybriarane diterpenoids, frajunolides L-O (1-4), were isolated from the Taiwanese gorgonian Junceella fragilis. The structures of compounds 1-4 were elucidated based on spectroscopic analysis, especially 2D NMR (1H-1H COSY, HSQC, HMBC and NOESY) and HRMS. Compounds 1 and 4 showed weak anti-inflammatory activity as tested by superoxide anion generation and elastase release by human neutrophil in response to fMLP/CB. Compound 3 showed selective inhibition on elastase release in vitro.

AB - Four new 8-hydroxybriarane diterpenoids, frajunolides L-O (1-4), were isolated from the Taiwanese gorgonian Junceella fragilis. The structures of compounds 1-4 were elucidated based on spectroscopic analysis, especially 2D NMR (1H-1H COSY, HSQC, HMBC and NOESY) and HRMS. Compounds 1 and 4 showed weak anti-inflammatory activity as tested by superoxide anion generation and elastase release by human neutrophil in response to fMLP/CB. Compound 3 showed selective inhibition on elastase release in vitro.

KW - 8-hydroxybriarane

KW - Anti-inflammatory activities

KW - Frajunolides

KW - Junceella fragilis

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DO - 10.3390/md9091477

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AN - SCOPUS:80053319788

SN - 1660-3397

VL - 9

SP - 1477

EP - 1486

JO - Marine Drugs

JF - Marine Drugs

IS - 9

ER -

Frajunolides L-O, four new 8-hydroxybriarane diterpenoids from the Gorgonian Junceella fragilis

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