Frequency of Epstein-Barr virus-associated gastric adenocarcinoma in Taiwan

Ling Ling Hsieh; Pay Jane Lin; Tse Ching Chen; Jonathan T. Ou

doi:10.1016/S0304-3835(98)00111-6

Frequency of Epstein-Barr virus-associated gastric adenocarcinoma in Taiwan

Ling Ling Hsieh, Pay Jane Lin, Tse Ching Chen, Jonathan T. Ou^*

^*Corresponding author for this work

Research output: Contribution to journal › Journal Article › peer-review

33 Scopus citations

Abstract

Eighty-two gastric adenocarcinomas (32 intestinal and 50 diffuse type) were investigated for the presence of Epstein-Barr virus (EBV) DNA by amplifying the 78-bp fragment from the EBNA1 gene with polymerase chain reaction. EBV was detected in 17 (20.7%) of the 82 gastric tumorous specimens. Of these 17 EBV-positive cases, only one was EBV-positive in the adjacent non-tumorous tissue. EBV-positive gastric adenocarcinoma was present in 15.6 and 24.0% of the intestinal and diffuse type tumors, respectively, but within the two classes there was significant non-homogeneity by type. EBV was found more frequently in adenocarcinomas of the tubular (25%) and poorly differentiated (30.3%) types. EBV involvement was found more in male than in female patients. Eighty of the 82 tumors were also checked for the prevalence of p53 gene mutation. Of the 17 EBV-positive gastric adenocarcinomas, only two showed p53 gene mutations. The p53 mutation rate was lower in EBV-positive tumors (11.8%) than in EBV-negative tumors (25.4%).

Original language	English
Pages (from-to)	125-129
Number of pages	5
Journal	Cancer Letters
Volume	129
Issue number	2
DOIs	https://doi.org/10.1016/S0304-3835(98)00111-6
State	Published - 19 06 1998

Keywords

EBV
Gastric cancer
p53 mutation

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/S0304-3835(98)00111-6

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title = "Frequency of Epstein-Barr virus-associated gastric adenocarcinoma in Taiwan",

abstract = "Eighty-two gastric adenocarcinomas (32 intestinal and 50 diffuse type) were investigated for the presence of Epstein-Barr virus (EBV) DNA by amplifying the 78-bp fragment from the EBNA1 gene with polymerase chain reaction. EBV was detected in 17 (20.7%) of the 82 gastric tumorous specimens. Of these 17 EBV-positive cases, only one was EBV-positive in the adjacent non-tumorous tissue. EBV-positive gastric adenocarcinoma was present in 15.6 and 24.0% of the intestinal and diffuse type tumors, respectively, but within the two classes there was significant non-homogeneity by type. EBV was found more frequently in adenocarcinomas of the tubular (25%) and poorly differentiated (30.3%) types. EBV involvement was found more in male than in female patients. Eighty of the 82 tumors were also checked for the prevalence of p53 gene mutation. Of the 17 EBV-positive gastric adenocarcinomas, only two showed p53 gene mutations. The p53 mutation rate was lower in EBV-positive tumors (11.8%) than in EBV-negative tumors (25.4%).",

keywords = "EBV, Gastric cancer, p53 mutation",

author = "Hsieh, {Ling Ling} and Lin, {Pay Jane} and Chen, {Tse Ching} and Ou, {Jonathan T.}",

year = "1998",

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doi = "10.1016/S0304-3835(98)00111-6",

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T1 - Frequency of Epstein-Barr virus-associated gastric adenocarcinoma in Taiwan

AU - Hsieh, Ling Ling

AU - Lin, Pay Jane

AU - Chen, Tse Ching

AU - Ou, Jonathan T.

PY - 1998/6/19

Y1 - 1998/6/19

N2 - Eighty-two gastric adenocarcinomas (32 intestinal and 50 diffuse type) were investigated for the presence of Epstein-Barr virus (EBV) DNA by amplifying the 78-bp fragment from the EBNA1 gene with polymerase chain reaction. EBV was detected in 17 (20.7%) of the 82 gastric tumorous specimens. Of these 17 EBV-positive cases, only one was EBV-positive in the adjacent non-tumorous tissue. EBV-positive gastric adenocarcinoma was present in 15.6 and 24.0% of the intestinal and diffuse type tumors, respectively, but within the two classes there was significant non-homogeneity by type. EBV was found more frequently in adenocarcinomas of the tubular (25%) and poorly differentiated (30.3%) types. EBV involvement was found more in male than in female patients. Eighty of the 82 tumors were also checked for the prevalence of p53 gene mutation. Of the 17 EBV-positive gastric adenocarcinomas, only two showed p53 gene mutations. The p53 mutation rate was lower in EBV-positive tumors (11.8%) than in EBV-negative tumors (25.4%).

AB - Eighty-two gastric adenocarcinomas (32 intestinal and 50 diffuse type) were investigated for the presence of Epstein-Barr virus (EBV) DNA by amplifying the 78-bp fragment from the EBNA1 gene with polymerase chain reaction. EBV was detected in 17 (20.7%) of the 82 gastric tumorous specimens. Of these 17 EBV-positive cases, only one was EBV-positive in the adjacent non-tumorous tissue. EBV-positive gastric adenocarcinoma was present in 15.6 and 24.0% of the intestinal and diffuse type tumors, respectively, but within the two classes there was significant non-homogeneity by type. EBV was found more frequently in adenocarcinomas of the tubular (25%) and poorly differentiated (30.3%) types. EBV involvement was found more in male than in female patients. Eighty of the 82 tumors were also checked for the prevalence of p53 gene mutation. Of the 17 EBV-positive gastric adenocarcinomas, only two showed p53 gene mutations. The p53 mutation rate was lower in EBV-positive tumors (11.8%) than in EBV-negative tumors (25.4%).

KW - EBV

KW - Gastric cancer

KW - p53 mutation

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DO - 10.1016/S0304-3835(98)00111-6

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SN - 0304-3835

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SP - 125

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JO - Cancer Letters

JF - Cancer Letters

IS - 2

ER -

Frequency of Epstein-Barr virus-associated gastric adenocarcinoma in Taiwan

Abstract

Keywords

UN SDGs

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