From phase diagram to the design of strontium-containing carrier

Ying Cen Chen; Pei Yi Hsu; W. Tuan; Po Liang Lai

doi:10.1080/21870764.2020.1774972

From phase diagram to the design of strontium-containing carrier

Ying Cen Chen, Pei Yi Hsu, W. Tuan^*, Po Liang Lai

^*Corresponding author for this work

School of Medicine

National Taiwan University

Research output: Contribution to journal › Journal Article › peer-review

7 Scopus citations

Abstract

Strontium (Sr) ions are known for its role on increasing bone mineral density. However, a high dosage through mouth may cause many side effects. An alternative to provide a low but steady release at the location of bone defect is therefore explored. In the present study, various amounts of strontium sulfate (SrSO₄) were dissolved into calcium sulfate (CaSO₄) at elevated temperatures. The release of Sr ions from the (Ca,Sr)SO₄ solid solution into various aqueous solutions was then measured. Through the control of Sr content in (Ca,Sr)SO₄, the Sr amount releasing into the aqueous solutions could be tailored. After implanting a solid solution into distal femur in rat, a low release of Sr into blood was confirmed.

Original language	English
Pages (from-to)	677-684
Number of pages	8
Journal	Journal of Asian Ceramic Societies
Volume	8
Issue number	3
DOIs	https://doi.org/10.1080/21870764.2020.1774972
State	Published - 02 07 2020

Bibliographical note

Publisher Copyright:
© 2020 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group on behalf of The Korean Ceramic Society and The Ceramic Society of Japan.

Keywords

Phase diagram
biomedical applications
calcium sulfate
solid solution
strontium

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10.1080/21870764.2020.1774972

Cite this

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abstract = "Strontium (Sr) ions are known for its role on increasing bone mineral density. However, a high dosage through mouth may cause many side effects. An alternative to provide a low but steady release at the location of bone defect is therefore explored. In the present study, various amounts of strontium sulfate (SrSO4) were dissolved into calcium sulfate (CaSO4) at elevated temperatures. The release of Sr ions from the (Ca,Sr)SO4 solid solution into various aqueous solutions was then measured. Through the control of Sr content in (Ca,Sr)SO4, the Sr amount releasing into the aqueous solutions could be tailored. After implanting a solid solution into distal femur in rat, a low release of Sr into blood was confirmed.",

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AB - Strontium (Sr) ions are known for its role on increasing bone mineral density. However, a high dosage through mouth may cause many side effects. An alternative to provide a low but steady release at the location of bone defect is therefore explored. In the present study, various amounts of strontium sulfate (SrSO4) were dissolved into calcium sulfate (CaSO4) at elevated temperatures. The release of Sr ions from the (Ca,Sr)SO4 solid solution into various aqueous solutions was then measured. Through the control of Sr content in (Ca,Sr)SO4, the Sr amount releasing into the aqueous solutions could be tailored. After implanting a solid solution into distal femur in rat, a low release of Sr into blood was confirmed.

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From phase diagram to the design of strontium-containing carrier

Abstract

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Keywords

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