Fulminant type 1 diabetes mellitus caused by drug hypersensitivity syndrome with human herpesvirus 6 infection

Chien Chun Chiou, Wen Hung Chung*, Shuen Iu Hung, Li Cheng Yang, Hong Shang Hong

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

76 Scopus citations

Abstract

Drug hypersensitivity syndrome (DHS) is an idiosyncratic and life-threatening adverse drug reaction characterized by skin rash and multiorgan involvement. In rare cases, fulminant type1 diabetes mellitus (DM) may develop after DHS. Among proposed pathogenesis, human herpesvirus 6 (HHV-6) infections may play a role in the development of DHS. We report a case of DHS associated with HHV-6 reactivation, complicated with a rare sequela of irreversible fulminant type 1 DM. No diabetes-related autoantibodies were detected. Early detection and intervention for this serious complication should be given in patients with DHS. Fulminant type1 DM associated with DHS is reviewed. The role of HHV-6 in DHS associated with fulminant type 1 DM is also discussed.

Original languageEnglish
Pages (from-to)S14-S17
JournalJournal of the American Academy of Dermatology
Volume54
Issue number2 SUPPL.
DOIs
StatePublished - 02 2006
Externally publishedYes

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