Function and pathological implications of exon junction complex factor Y14

Tzu Wei Chuang; Kou Ming Lee; Woan Yuh Tarn

doi:10.3390/biom5020343

Function and pathological implications of exon junction complex factor Y14

Tzu Wei Chuang
, Kou Ming Lee
, Woan Yuh Tarn^*

^*Corresponding author for this work

Academia Sinica - Institute of Biomedical Sciences

Research output: Contribution to journal › Review article › peer-review

25 Scopus citations

Abstract

Eukaryotic mRNA biogenesis involves a series of interconnected steps, including nuclear pre-mRNA processing, mRNA export, and surveillance. The exon-junction complex (EJC) is deposited on newly spliced mRNAs and coordinates several downstream steps of mRNA biogenesis. The EJC core protein, Y14, functions with its partners in nonsense-mediated mRNA decay and translational enhancement. Y14 plays additional roles in mRNA metabolism, some of which are independent of the EJC, and it is also involved in other cellular processes. Genetic mutations or aberrant expression of Y14 results in physiological abnormality and may cause disease. Therefore, it is important to understand the various functions of Y14 and its physiological and pathological roles.

Original language	English
Pages (from-to)	343-355
Number of pages	13
Journal	Biomolecules
Volume	5
Issue number	2
DOIs	https://doi.org/10.3390/biom5020343
State	Published - 10 04 2015
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2015 by the authors; licensee MDPI, Basel, Switzerland.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Centrosome
Exon-junction complex
Nonsense-mediated mRNA decay
Pre-mRNA splicing
Translation

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10.3390/biom5020343

Cite this

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title = "Function and pathological implications of exon junction complex factor Y14",

abstract = "Eukaryotic mRNA biogenesis involves a series of interconnected steps, including nuclear pre-mRNA processing, mRNA export, and surveillance. The exon-junction complex (EJC) is deposited on newly spliced mRNAs and coordinates several downstream steps of mRNA biogenesis. The EJC core protein, Y14, functions with its partners in nonsense-mediated mRNA decay and translational enhancement. Y14 plays additional roles in mRNA metabolism, some of which are independent of the EJC, and it is also involved in other cellular processes. Genetic mutations or aberrant expression of Y14 results in physiological abnormality and may cause disease. Therefore, it is important to understand the various functions of Y14 and its physiological and pathological roles.",

keywords = "Centrosome, Exon-junction complex, Nonsense-mediated mRNA decay, Pre-mRNA splicing, Translation",

author = "Chuang, \{Tzu Wei\} and Lee, \{Kou Ming\} and Tarn, \{Woan Yuh\}",

note = "Publisher Copyright: {\textcopyright} 2015 by the authors; licensee MDPI, Basel, Switzerland.",

year = "2015",

month = apr,

day = "10",

doi = "10.3390/biom5020343",

language = "英语",

volume = "5",

pages = "343--355",

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TY - JOUR

T1 - Function and pathological implications of exon junction complex factor Y14

AU - Chuang, Tzu Wei

AU - Lee, Kou Ming

AU - Tarn, Woan Yuh

PY - 2015/4/10

Y1 - 2015/4/10

N2 - Eukaryotic mRNA biogenesis involves a series of interconnected steps, including nuclear pre-mRNA processing, mRNA export, and surveillance. The exon-junction complex (EJC) is deposited on newly spliced mRNAs and coordinates several downstream steps of mRNA biogenesis. The EJC core protein, Y14, functions with its partners in nonsense-mediated mRNA decay and translational enhancement. Y14 plays additional roles in mRNA metabolism, some of which are independent of the EJC, and it is also involved in other cellular processes. Genetic mutations or aberrant expression of Y14 results in physiological abnormality and may cause disease. Therefore, it is important to understand the various functions of Y14 and its physiological and pathological roles.

AB - Eukaryotic mRNA biogenesis involves a series of interconnected steps, including nuclear pre-mRNA processing, mRNA export, and surveillance. The exon-junction complex (EJC) is deposited on newly spliced mRNAs and coordinates several downstream steps of mRNA biogenesis. The EJC core protein, Y14, functions with its partners in nonsense-mediated mRNA decay and translational enhancement. Y14 plays additional roles in mRNA metabolism, some of which are independent of the EJC, and it is also involved in other cellular processes. Genetic mutations or aberrant expression of Y14 results in physiological abnormality and may cause disease. Therefore, it is important to understand the various functions of Y14 and its physiological and pathological roles.

KW - Centrosome

KW - Exon-junction complex

KW - Nonsense-mediated mRNA decay

KW - Pre-mRNA splicing

KW - Translation

UR - https://www.scopus.com/pages/publications/84967333010

U2 - 10.3390/biom5020343

DO - 10.3390/biom5020343

M3 - 文献综述

C2 - 25866920

AN - SCOPUS:84967333010

SN - 2218-273X

VL - 5

SP - 343

EP - 355

JO - Biomolecules

JF - Biomolecules

IS - 2

ER -

Function and pathological implications of exon junction complex factor Y14

Abstract

Bibliographical note

UN SDGs

Keywords

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