Functional and Anatomical Outcomes of Anti-Vascular Endothelial Growth Factor Treatment for Exudative Age-Related Macular Degeneration with or without Obstructive Sleep Apnea

Nan Ni Chen, Chau Yin Chen, Jin Jhe Wang, Heng Chiao Huang, Wei Dar Chen, Ching Lung Chen, Yao Hsu Yang, Meng Hung Lin, Ting Yu Kuo, Chien Hsiung Lai*

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

Abstract

(1) To investigate the functional and anatomical outcomes of anti-vascular endothelial growth factor (anti-VEGF) treatment in patients with exudative age-related macular degeneration (AMD) with or without obstructive sleep apnea (OSA); (2) In total, 65 patients with AMD with or without OSA who received three consecutive doses of intravitreal anti-VEGF injections were enrolled. The primary outcomes—best-corrected visual acuity (BCVA) and central macular thickness (CMT)—were assessed at 1 and 3 months. Moreover, morphological changes observed through optical coherence tomography were analyzed; (3) In total, 15 of the 65 patients had OSA and were included in the OSA group; the remaining 50 patients were included in the non-OSA (control) group. At 1 and 3 months after treatment, BCVA and CMT had improved but did not differ significantly between the groups. More patients in the OSA group demonstrated subretinal fluid (SRF) resorption at 3 months after treatment than in the non-OSA group (p = 0.009). Changes in other imaging biomarkers, such as intraretinal cysts, retinal pigment epithelium detachment, hyperreflective dots, and ellipsoid zone disruptions, did not differ significantly between the groups; (4) Our results suggest that the BCVA and CMT outcomes 3 months after anti-VEGF treatment are similar between patients with and without OSA. Moreover, patients with OSA may exhibit superior SRF resorption. A large-scale prospective study is mandatory to evaluate the association between SRF resorption and visual outcomes in AMD patients with OSA.

Original languageEnglish
Article number7285
JournalInternational Journal of Molecular Sciences
Volume24
Issue number8
DOIs
StatePublished - 14 04 2023

Bibliographical note

Publisher Copyright:
© 2023 by the authors.

Keywords

  • age-related macular degeneration
  • anti-vascular endothelial growth factor treatment
  • obstructive sleep apnea
  • Vascular Endothelial Growth Factor A
  • Prospective Studies
  • Vascular Endothelial Growth Factors
  • Humans
  • Macular Degeneration/complications
  • Sleep Apnea, Obstructive/complications
  • Treatment Outcome
  • Angiogenesis Inhibitors/therapeutic use
  • Ranibizumab/therapeutic use
  • Tomography, Optical Coherence/methods

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