Functional connectivity altering in hippocampus with closed-loop deep brain stimulation

Cihun Siyong Alex Gong; Yuan Ting Tsai; Ji An Chen; Hsin Yi Lai; Wei Che Wei; You Yin Chen

doi:10.1109/ICCE-TW.2014.6904106

Functional connectivity altering in hippocampus with closed-loop deep brain stimulation

Cihun Siyong Alex Gong^*, Yuan Ting Tsai, Ji An Chen, Hsin Yi Lai, Wei Che Wei, You Yin Chen

^*Corresponding author for this work

Department of Electrical Engineering

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

1 Scopus citations

Abstract

Hippocampus is considered as the main role of memory consolidation. Learning can be completed after memory consolidation. The thalamus plays an important role in consciousness. In past research had supported that that stimulation in the central lateral thalamus could enhance the learning behavioral. Here, we present an investigational platform including: an implanted sensing and stimulation components to collect data and run the closed-loop algorithm with real-time spectrum measurement. The prototyping system was demonstrated in a chronic animal model studying hippocampal dynamics. We used the platform to find the biomarker, that the theta (θ) spectral band power of local field potentials (LFPs) could be a control variable of interest when modulating hippocampal network state after central lateral thalamic stimulation. The platform is designed to be a flexible prototyping tool and could be used to develop improved mechanistic models and automated closed-loop systems for a variety of neurological disorders.

Original language	English
Title of host publication	Digest of Technical Papers - IEEE International Conference on Consumer Electronics
Publisher	Institute of Electrical and Electronics Engineers Inc.
Pages	7-8
Number of pages	2
ISBN (Electronic)	9781479938308
DOIs	https://doi.org/10.1109/ICCE-TW.2014.6904106
State	Published - 18 09 2014
Event	1st IEEE International Conference on Consumer Electronics - Taiwan, ICCE-TW 2014 - Taipei, Taiwan Duration: 26 05 2014 → 28 05 2014

Publication series

Name	Digest of Technical Papers - IEEE International Conference on Consumer Electronics
ISSN (Print)	0747-668X

Conference

Conference	1st IEEE International Conference on Consumer Electronics - Taiwan, ICCE-TW 2014
Country/Territory	Taiwan
City	Taipei
Period	26/05/14 → 28/05/14

Bibliographical note

Publisher Copyright:
© 2014 IEEE.

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10.1109/ICCE-TW.2014.6904106

Cite this

Gong, C. S. A., Tsai, Y. T., Chen, J. A., Lai, H. Y., Wei, W. C., & Chen, Y. Y. (2014). Functional connectivity altering in hippocampus with closed-loop deep brain stimulation. In Digest of Technical Papers - IEEE International Conference on Consumer Electronics (pp. 7-8). Article 6904106 (Digest of Technical Papers - IEEE International Conference on Consumer Electronics). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/ICCE-TW.2014.6904106

Gong, Cihun Siyong Alex ; Tsai, Yuan Ting ; Chen, Ji An et al. / Functional connectivity altering in hippocampus with closed-loop deep brain stimulation. Digest of Technical Papers - IEEE International Conference on Consumer Electronics. Institute of Electrical and Electronics Engineers Inc., 2014. pp. 7-8 (Digest of Technical Papers - IEEE International Conference on Consumer Electronics).

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abstract = "Hippocampus is considered as the main role of memory consolidation. Learning can be completed after memory consolidation. The thalamus plays an important role in consciousness. In past research had supported that that stimulation in the central lateral thalamus could enhance the learning behavioral. Here, we present an investigational platform including: an implanted sensing and stimulation components to collect data and run the closed-loop algorithm with real-time spectrum measurement. The prototyping system was demonstrated in a chronic animal model studying hippocampal dynamics. We used the platform to find the biomarker, that the theta (θ) spectral band power of local field potentials (LFPs) could be a control variable of interest when modulating hippocampal network state after central lateral thalamic stimulation. The platform is designed to be a flexible prototyping tool and could be used to develop improved mechanistic models and automated closed-loop systems for a variety of neurological disorders.",

author = "Gong, {Cihun Siyong Alex} and Tsai, {Yuan Ting} and Chen, {Ji An} and Lai, {Hsin Yi} and Wei, {Wei Che} and Chen, {You Yin}",

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Gong, CSA, Tsai, YT, Chen, JA, Lai, HY, Wei, WC & Chen, YY 2014, Functional connectivity altering in hippocampus with closed-loop deep brain stimulation. in Digest of Technical Papers - IEEE International Conference on Consumer Electronics., 6904106, Digest of Technical Papers - IEEE International Conference on Consumer Electronics, Institute of Electrical and Electronics Engineers Inc., pp. 7-8, 1st IEEE International Conference on Consumer Electronics - Taiwan, ICCE-TW 2014, Taipei, Taiwan, 26/05/14. https://doi.org/10.1109/ICCE-TW.2014.6904106

Functional connectivity altering in hippocampus with closed-loop deep brain stimulation. / Gong, Cihun Siyong Alex; Tsai, Yuan Ting; Chen, Ji An et al.
Digest of Technical Papers - IEEE International Conference on Consumer Electronics. Institute of Electrical and Electronics Engineers Inc., 2014. p. 7-8 6904106 (Digest of Technical Papers - IEEE International Conference on Consumer Electronics).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

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AU - Chen, You Yin

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AB - Hippocampus is considered as the main role of memory consolidation. Learning can be completed after memory consolidation. The thalamus plays an important role in consciousness. In past research had supported that that stimulation in the central lateral thalamus could enhance the learning behavioral. Here, we present an investigational platform including: an implanted sensing and stimulation components to collect data and run the closed-loop algorithm with real-time spectrum measurement. The prototyping system was demonstrated in a chronic animal model studying hippocampal dynamics. We used the platform to find the biomarker, that the theta (θ) spectral band power of local field potentials (LFPs) could be a control variable of interest when modulating hippocampal network state after central lateral thalamic stimulation. The platform is designed to be a flexible prototyping tool and could be used to develop improved mechanistic models and automated closed-loop systems for a variety of neurological disorders.

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Gong CSA, Tsai YT, Chen JA, Lai HY, Wei WC, Chen YY. Functional connectivity altering in hippocampus with closed-loop deep brain stimulation. In Digest of Technical Papers - IEEE International Conference on Consumer Electronics. Institute of Electrical and Electronics Engineers Inc. 2014. p. 7-8. 6904106. (Digest of Technical Papers - IEEE International Conference on Consumer Electronics). doi: 10.1109/ICCE-TW.2014.6904106

Functional connectivity altering in hippocampus with closed-loop deep brain stimulation

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