Functional Role of Mitochondrial DNA in Cancer Progression

Yang Hsiang Lin; Siew Na Lim; Cheng Yi Chen; Hsiang Cheng Chi; Chau Ting Yeh; Wey Ran Lin

doi:10.3390/ijms23031659

Functional Role of Mitochondrial DNA in Cancer Progression

Yang Hsiang Lin
, Siew Na Lim
, Cheng Yi Chen
, Hsiang Cheng Chi
, Chau Ting Yeh^*
, Wey Ran Lin^*

^*Corresponding author for this work

School of Medicine

Chang Gung Memorial Hospital
Chang Gung University
National Cheng Kung University
China Medical University Taichung

Research output: Contribution to journal › Review article › peer-review

58 Scopus citations

Abstract

Mitochondrial DNA (mtDNA) has been identified as a significant genetic biomarker in disease, cancer and evolution. Mitochondria function as modulators for regulating cellular metab-olism. In the clinic, mtDNA variations (mutations/single nucleotide polymorphisms) and dysreg-ulation of mitochondria-encoded genes are associated with survival outcomes among cancer pa-tients. On the other hand, nuclear-encoded genes have been found to regulate mitochon-dria-encoded gene expression, in turn regulating mitochondrial homeostasis. These observations suggest that the crosstalk between the nuclear genome and mitochondrial genome is important for cellular function. Therefore, this review summarizes the significant mechanisms and functional roles of mtDNA variations (DNA level) and mtDNA-encoded genes (RNA and protein levels) in cancers and discusses new mechanisms of crosstalk between mtDNA and the nuclear genome.

Original language	English
Article number	1659
Journal	International Journal of Molecular Sciences
Volume	23
Issue number	3
DOIs	https://doi.org/10.3390/ijms23031659
State	Published - 01 02 2022

Bibliographical note

Publisher Copyright:
© 2022 by the authors. Licensee MDPI, Basel, Switzerland.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Cancer
Mitochondria
Mutation
NcRNA
Prognostic marker
SNP

Access to Document

10.3390/ijms23031659

Cite this

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title = "Functional Role of Mitochondrial DNA in Cancer Progression",

abstract = "Mitochondrial DNA (mtDNA) has been identified as a significant genetic biomarker in disease, cancer and evolution. Mitochondria function as modulators for regulating cellular metab-olism. In the clinic, mtDNA variations (mutations/single nucleotide polymorphisms) and dysreg-ulation of mitochondria-encoded genes are associated with survival outcomes among cancer pa-tients. On the other hand, nuclear-encoded genes have been found to regulate mitochon-dria-encoded gene expression, in turn regulating mitochondrial homeostasis. These observations suggest that the crosstalk between the nuclear genome and mitochondrial genome is important for cellular function. Therefore, this review summarizes the significant mechanisms and functional roles of mtDNA variations (DNA level) and mtDNA-encoded genes (RNA and protein levels) in cancers and discusses new mechanisms of crosstalk between mtDNA and the nuclear genome.",

keywords = "Cancer, Mitochondria, Mutation, NcRNA, Prognostic marker, SNP",

author = "Lin, \{Yang Hsiang\} and Lim, \{Siew Na\} and Chen, \{Cheng Yi\} and Chi, \{Hsiang Cheng\} and Yeh, \{Chau Ting\} and Lin, \{Wey Ran\}",

note = "Publisher Copyright: {\textcopyright} 2022 by the authors. Licensee MDPI, Basel, Switzerland.",

year = "2022",

month = feb,

day = "1",

doi = "10.3390/ijms23031659",

language = "英语",

volume = "23",

journal = "International Journal of Molecular Sciences",

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TY - JOUR

T1 - Functional Role of Mitochondrial DNA in Cancer Progression

AU - Lin, Yang Hsiang

AU - Lim, Siew Na

AU - Chen, Cheng Yi

AU - Chi, Hsiang Cheng

AU - Yeh, Chau Ting

AU - Lin, Wey Ran

PY - 2022/2/1

Y1 - 2022/2/1

N2 - Mitochondrial DNA (mtDNA) has been identified as a significant genetic biomarker in disease, cancer and evolution. Mitochondria function as modulators for regulating cellular metab-olism. In the clinic, mtDNA variations (mutations/single nucleotide polymorphisms) and dysreg-ulation of mitochondria-encoded genes are associated with survival outcomes among cancer pa-tients. On the other hand, nuclear-encoded genes have been found to regulate mitochon-dria-encoded gene expression, in turn regulating mitochondrial homeostasis. These observations suggest that the crosstalk between the nuclear genome and mitochondrial genome is important for cellular function. Therefore, this review summarizes the significant mechanisms and functional roles of mtDNA variations (DNA level) and mtDNA-encoded genes (RNA and protein levels) in cancers and discusses new mechanisms of crosstalk between mtDNA and the nuclear genome.

AB - Mitochondrial DNA (mtDNA) has been identified as a significant genetic biomarker in disease, cancer and evolution. Mitochondria function as modulators for regulating cellular metab-olism. In the clinic, mtDNA variations (mutations/single nucleotide polymorphisms) and dysreg-ulation of mitochondria-encoded genes are associated with survival outcomes among cancer pa-tients. On the other hand, nuclear-encoded genes have been found to regulate mitochon-dria-encoded gene expression, in turn regulating mitochondrial homeostasis. These observations suggest that the crosstalk between the nuclear genome and mitochondrial genome is important for cellular function. Therefore, this review summarizes the significant mechanisms and functional roles of mtDNA variations (DNA level) and mtDNA-encoded genes (RNA and protein levels) in cancers and discusses new mechanisms of crosstalk between mtDNA and the nuclear genome.

KW - Cancer

KW - Mitochondria

KW - Mutation

KW - NcRNA

KW - Prognostic marker

KW - SNP

UR - https://www.scopus.com/pages/publications/85123583009

U2 - 10.3390/ijms23031659

DO - 10.3390/ijms23031659

M3 - 文献综述

C2 - 35163579

AN - SCOPUS:85123583009

SN - 1661-6596

VL - 23

JO - International Journal of Molecular Sciences

JF - International Journal of Molecular Sciences

IS - 3

M1 - 1659

ER -

Functional Role of Mitochondrial DNA in Cancer Progression

Abstract

Bibliographical note

UN SDGs

Keywords

Access to Document

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