GADL1 variant and medication adherence in predicting response to lithium maintenance treatment in bipolar I disorder

Chih Ken Chen; Chau Shoun Lee; Hsuan Yu Chen; Lawrence Shih Hsin Wu; Jung Chen Chang; Chia Yih Liu; Andrew Tai Ann Cheng

doi:10.1192/bjpo.bp.116.002881

GADL1 variant and medication adherence in predicting response to lithium maintenance treatment in bipolar I disorder

Chih Ken Chen, Chau Shoun Lee, Hsuan Yu Chen, Lawrence Shih Hsin Wu, Jung Chen Chang, Chia Yih Liu, Andrew Tai Ann Cheng^*

^*Corresponding author for this work

School of Medicine

Research output: Contribution to journal › Journal Article › peer-review

16 Scopus citations

Abstract

Background Genetic variants and medication adherence have been identified to be the main factors contributing to lithium treatment response in bipolar disorders. Aims To simultaneously examine effects of variant glutamate decarboxylase-like protein 1 (GADL1) and medication adherence on response to lithium maintenance treatment in Han Chinese patients with bipolar I (BPI) disorder. Method Frequencies of manic and depressive episodes between carriers and non-carriers of the effective GADL1 rs17026688 T allele during the cumulative periods of off-lithium, poor adherence to lithium treatment and good adherence to lithium treatment were compared in Han Chinese patients with BPI disorder (n=215). Results GADL1 rs17026688 T carriers had significantly lower frequencies of recurrent affective episodes than non-T carriers during the cumulative period of good adherence, but not during those of poor adherence. Conclusions GADL1 rs17026688 and medication adherence jointly predict response to lithium maintenance treatment in Han Chinese BPI patients. Declaration of interest None.

Original language	English
Pages (from-to)	301-306
Number of pages	6
Journal	BJPsych Open
Volume	2
Issue number	5
DOIs	https://doi.org/10.1192/bjpo.bp.116.002881
State	Published - 2016

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Publisher Copyright:
© The Royal College of Psychiatrists 2016.

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@article{163b142292c34faeb17f25b7be54084c,

title = "GADL1 variant and medication adherence in predicting response to lithium maintenance treatment in bipolar I disorder",

abstract = "Background Genetic variants and medication adherence have been identified to be the main factors contributing to lithium treatment response in bipolar disorders. Aims To simultaneously examine effects of variant glutamate decarboxylase-like protein 1 (GADL1) and medication adherence on response to lithium maintenance treatment in Han Chinese patients with bipolar I (BPI) disorder. Method Frequencies of manic and depressive episodes between carriers and non-carriers of the effective GADL1 rs17026688 T allele during the cumulative periods of off-lithium, poor adherence to lithium treatment and good adherence to lithium treatment were compared in Han Chinese patients with BPI disorder (n=215). Results GADL1 rs17026688 T carriers had significantly lower frequencies of recurrent affective episodes than non-T carriers during the cumulative period of good adherence, but not during those of poor adherence. Conclusions GADL1 rs17026688 and medication adherence jointly predict response to lithium maintenance treatment in Han Chinese BPI patients. Declaration of interest None.",

author = "Chen, {Chih Ken} and Lee, {Chau Shoun} and Chen, {Hsuan Yu} and Wu, {Lawrence Shih Hsin} and Chang, {Jung Chen} and Liu, {Chia Yih} and Cheng, {Andrew Tai Ann}",

note = "Publisher Copyright: {\textcopyright} The Royal College of Psychiatrists 2016.",

year = "2016",

doi = "10.1192/bjpo.bp.116.002881",

language = "英语",

volume = "2",

pages = "301--306",

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issn = "2056-4724",

publisher = "Cambridge University Press",

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TY - JOUR

T1 - GADL1 variant and medication adherence in predicting response to lithium maintenance treatment in bipolar I disorder

AU - Chen, Chih Ken

AU - Lee, Chau Shoun

AU - Chen, Hsuan Yu

AU - Wu, Lawrence Shih Hsin

AU - Chang, Jung Chen

AU - Liu, Chia Yih

AU - Cheng, Andrew Tai Ann

PY - 2016

Y1 - 2016

N2 - Background Genetic variants and medication adherence have been identified to be the main factors contributing to lithium treatment response in bipolar disorders. Aims To simultaneously examine effects of variant glutamate decarboxylase-like protein 1 (GADL1) and medication adherence on response to lithium maintenance treatment in Han Chinese patients with bipolar I (BPI) disorder. Method Frequencies of manic and depressive episodes between carriers and non-carriers of the effective GADL1 rs17026688 T allele during the cumulative periods of off-lithium, poor adherence to lithium treatment and good adherence to lithium treatment were compared in Han Chinese patients with BPI disorder (n=215). Results GADL1 rs17026688 T carriers had significantly lower frequencies of recurrent affective episodes than non-T carriers during the cumulative period of good adherence, but not during those of poor adherence. Conclusions GADL1 rs17026688 and medication adherence jointly predict response to lithium maintenance treatment in Han Chinese BPI patients. Declaration of interest None.

AB - Background Genetic variants and medication adherence have been identified to be the main factors contributing to lithium treatment response in bipolar disorders. Aims To simultaneously examine effects of variant glutamate decarboxylase-like protein 1 (GADL1) and medication adherence on response to lithium maintenance treatment in Han Chinese patients with bipolar I (BPI) disorder. Method Frequencies of manic and depressive episodes between carriers and non-carriers of the effective GADL1 rs17026688 T allele during the cumulative periods of off-lithium, poor adherence to lithium treatment and good adherence to lithium treatment were compared in Han Chinese patients with BPI disorder (n=215). Results GADL1 rs17026688 T carriers had significantly lower frequencies of recurrent affective episodes than non-T carriers during the cumulative period of good adherence, but not during those of poor adherence. Conclusions GADL1 rs17026688 and medication adherence jointly predict response to lithium maintenance treatment in Han Chinese BPI patients. Declaration of interest None.

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U2 - 10.1192/bjpo.bp.116.002881

DO - 10.1192/bjpo.bp.116.002881

M3 - 文章

AN - SCOPUS:85024399157

SN - 2056-4724

VL - 2

SP - 301

EP - 306

JO - BJPsych Open

JF - BJPsych Open

IS - 5

ER -

GADL1 variant and medication adherence in predicting response to lithium maintenance treatment in bipolar I disorder

Abstract

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