Gadolinium vanadate nanosheets entrapped with 1D-halloysite nanotubes-based nanocomposite for the determination of prostate anticancer drug nilutamide

High-performance, low-cost electrode materials with distinct structural characteristics are still needed for electrochemical sensors. In this paper, 1D-halloysite nanotubes are embedded over 2D nanosheets of gadolinium vanadate nanosheets (GdV/HNT), which are hydrothermally constructed for the first time. Structural and physicochemical evaluations reveal the essential properties of the produced composite material. Because of the 3D flower-like morphology, it was simpler to establish contact with the HNT with GdV NS, which had developed. The anti-prostate cancer drug nilutamide (NLT) was then examined utilizing voltammetric methods on a GdV/HNT nanocomposite modified glassy carbon electrode (GdV/HNT/GCE). For NLT detection, the nanocomposite material GdV/HNT/GCE demonstrates high electrochemical efficiency because of its synergy, many active sites, and quick electron transfer. Under ideal conditions, the GdV/HNT nanocomposite-based electrochemical sensor can achieve a wide linear range (0.5–478 µM), low detection limit (1.8 nM), strong sensitivity (1.33 µA µM⁻¹ cm⁻²), high repeatability, and significant recovery results in actual sample analysis are all possible with the GdV/HNT nanocomposite-based electrochemical sensor under optimal circumstances. Electrochemical sensors for NLT trace-level detection with simple manufacturing and high activity are shown in this study.