Garcimultiflorone G, a novel benzoylphloroglucinol derivative from Garcinia multiflora with inhibitory activity on neutrophil pro-inflammatory responses

Chia Wei Ting; Tsong Long Hwang; Ih Sheng Chen; Ming Jen Cheng; Ping Jyun Sung; Ming Hong Yen; Jih Jung Chen

doi:10.1002/cbdv.201300278

Garcimultiflorone G, a novel benzoylphloroglucinol derivative from Garcinia multiflora with inhibitory activity on neutrophil pro-inflammatory responses

Chia Wei Ting, Tsong Long Hwang, Ih Sheng Chen, Ming Jen Cheng, Ping Jyun Sung, Ming Hong Yen^*, Jih Jung Chen

^*Corresponding author for this work

School of Traditional Chinese Medicine

Research output: Contribution to journal › Journal Article › peer-review

24 Scopus citations

Abstract

A novel benzoylphloroglucinol derivative, garcimultiflorone G (1), was isolated from the fruits of Garcinia multiflora. The structure of 1 was determined through extensive 1D- and 2D-NMR, and MS analyses. Garcimultiflorone G (1) showed inhibitory effects against superoxide anion (O₂ ^̇-) generation and elastase release by human neutrophils in response to formyl-L-methionyl-L-leucyl-L-phenylalanine/cytochalasin B (fMLP/CB), with IC₅₀ values of 6.97±1.56 and 11.70±1.58 μM, respectively.

Original language	English
Pages (from-to)	819-824
Number of pages	6
Journal	Chemistry and Biodiversity
Volume	11
Issue number	5
DOIs	https://doi.org/10.1002/cbdv.201300278
State	Published - 05 2014

Keywords

Biological activity
Garcimultiflorone G
Garcinia multiflora

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title = "Garcimultiflorone G, a novel benzoylphloroglucinol derivative from Garcinia multiflora with inhibitory activity on neutrophil pro-inflammatory responses",

abstract = "A novel benzoylphloroglucinol derivative, garcimultiflorone G (1), was isolated from the fruits of Garcinia multiflora. The structure of 1 was determined through extensive 1D- and 2D-NMR, and MS analyses. Garcimultiflorone G (1) showed inhibitory effects against superoxide anion (O2{\. }-) generation and elastase release by human neutrophils in response to formyl-L-methionyl-L-leucyl-L-phenylalanine/cytochalasin B (fMLP/CB), with IC50 values of 6.97±1.56 and 11.70±1.58 μM, respectively.",

keywords = "Biological activity, Garcimultiflorone G, Garcinia multiflora",

author = "Ting, \{Chia Wei\} and Hwang, \{Tsong Long\} and Chen, \{Ih Sheng\} and Cheng, \{Ming Jen\} and Sung, \{Ping Jyun\} and Yen, \{Ming Hong\} and Chen, \{Jih Jung\}",

year = "2014",

month = may,

doi = "10.1002/cbdv.201300278",

language = "英语",

volume = "11",

pages = "819--824",

journal = "Chemistry and Biodiversity",

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TY - JOUR

T1 - Garcimultiflorone G, a novel benzoylphloroglucinol derivative from Garcinia multiflora with inhibitory activity on neutrophil pro-inflammatory responses

AU - Ting, Chia Wei

AU - Hwang, Tsong Long

AU - Chen, Ih Sheng

AU - Cheng, Ming Jen

AU - Sung, Ping Jyun

AU - Yen, Ming Hong

AU - Chen, Jih Jung

PY - 2014/5

Y1 - 2014/5

N2 - A novel benzoylphloroglucinol derivative, garcimultiflorone G (1), was isolated from the fruits of Garcinia multiflora. The structure of 1 was determined through extensive 1D- and 2D-NMR, and MS analyses. Garcimultiflorone G (1) showed inhibitory effects against superoxide anion (O2 ̇-) generation and elastase release by human neutrophils in response to formyl-L-methionyl-L-leucyl-L-phenylalanine/cytochalasin B (fMLP/CB), with IC50 values of 6.97±1.56 and 11.70±1.58 μM, respectively.

AB - A novel benzoylphloroglucinol derivative, garcimultiflorone G (1), was isolated from the fruits of Garcinia multiflora. The structure of 1 was determined through extensive 1D- and 2D-NMR, and MS analyses. Garcimultiflorone G (1) showed inhibitory effects against superoxide anion (O2 ̇-) generation and elastase release by human neutrophils in response to formyl-L-methionyl-L-leucyl-L-phenylalanine/cytochalasin B (fMLP/CB), with IC50 values of 6.97±1.56 and 11.70±1.58 μM, respectively.

KW - Biological activity

KW - Garcimultiflorone G

KW - Garcinia multiflora

UR - https://www.scopus.com/pages/publications/84900834789

U2 - 10.1002/cbdv.201300278

DO - 10.1002/cbdv.201300278

M3 - 文章

C2 - 24827693

AN - SCOPUS:84900834789

SN - 1612-1872

VL - 11

SP - 819

EP - 824

JO - Chemistry and Biodiversity

JF - Chemistry and Biodiversity

IS - 5

ER -

Garcimultiflorone G, a novel benzoylphloroglucinol derivative from Garcinia multiflora with inhibitory activity on neutrophil pro-inflammatory responses

Abstract

Keywords

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