Gd2O(CO3)2 · H2O particles and the corresponding Gd2O3: Synthesis and applications of magnetic resonance contrast agents and template particles for hollow spheres and hybrid composites

I. Fang Li; Chia Hao Su; Hwo Shuenn Sheu; Hui Chi Chiu; Yi Wei Lo; Wei Ting Lin; Jyh Horng Chen; Chen Sheng Yeh

doi:10.1002/adfm.200700702

Gd₂O(CO₃)₂ · H₂O particles and the corresponding Gd₂O₃: Synthesis and applications of magnetic resonance contrast agents and template particles for hollow spheres and hybrid composites

I. Fang Li^*
, Chia Hao Su
, Hwo Shuenn Sheu
, Hui Chi Chiu
, Yi Wei Lo
, Wei Ting Lin
, Jyh Horng Chen
, Chen Sheng Yeh

^*Corresponding author for this work

National Cheng Kung University
National Taiwan University
National Synchrotron Radiation Research Center Taiwan

Research output: Contribution to journal › Journal Article › peer-review

156 Scopus citations

Abstract

The solution approach was employed to yield multifunctional amorphous Gd₂O(CO₃)₂ · H₂O colloidal spheres by reflux of an aqueous solution containing GdCl₃ · 6H₂O and urea, By elongating the reaction time, crystalline rhombus-shaped Gd₂O(CO₃)₂ · H ₂O with at least 87% yield could be formed and were also accompanied by some rectangular particles. High-resolution synchrotron powder X-ray diffraction provides crystal structure information, such as cell dimensions, and indexes the exact crystal packing with hexagonal symmetry, which is absent from the Joint Committee on Powder Diffraction Standards file, for the crystalline rhombus sample. Particle formation was studied based on the reaction time and the concentration ratio of [urea]/ [GdCl₃ · 6H₂O). After a calcination process, the amorphous spheres and crystalline rhombus Gd₂O(CO₃)₂ · H₂O particles convert in to crystalline Gd₂O₃ at temperatures above 600°C. For in vitro magnetic resonance imaging (MRI), both Gd ₂O(CO₃)₂ · H₂O and Gd ₂O₃ species show the promising T₁- and T ₂-weighted effects and could potentially serve as bimodal T ₁-positive and T₂-negative contrast agents. The amorphous Gd₂O(CO₃)₂ · H₂O contrast agent further demonstrates enhanced contrast of the liver and kidney using a dynamic contrast-enhanced MR imaging (DCE-MRI) technique for in vivo investigation. The multifunctional capability of he amorphous Gd ₂O(CO₃)₂ · H₂O spheres was also evidenced by the formation of nanoshells using these amorphous spheres as the template. Surface engineering of the amorphous Gd₂O(CO ₃)₂ · H₂O spheres could be performed by covalent bonding to form hollow silica nanoshells and hollow silica@Fe ₃O₄ hybrid particles.

Original language	English
Pages (from-to)	766-776
Number of pages	11
Journal	Advanced Functional Materials
Volume	18
Issue number	5
DOIs	https://doi.org/10.1002/adfm.200700702
State	Published - 11 03 2008
Externally published	Yes

Access to Document

10.1002/adfm.200700702

Cite this

Li, I. F., Su, C. H., Sheu, H. S., Chiu, H. C., Lo, Y. W., Lin, W. T., Chen, J. H., & Yeh, C. S. (2008). Gd₂O(CO₃)₂ · H₂O particles and the corresponding Gd₂O₃: Synthesis and applications of magnetic resonance contrast agents and template particles for hollow spheres and hybrid composites. Advanced Functional Materials, 18(5), 766-776. https://doi.org/10.1002/adfm.200700702

@article{66cfd2d247224120854ffe5c00f66a02,

title = "Gd2O(CO3)2 · H2O particles and the corresponding Gd2O3: Synthesis and applications of magnetic resonance contrast agents and template particles for hollow spheres and hybrid composites",

abstract = "The solution approach was employed to yield multifunctional amorphous Gd2O(CO3)2 · H2O colloidal spheres by reflux of an aqueous solution containing GdCl3 · 6H2O and urea, By elongating the reaction time, crystalline rhombus-shaped Gd2O(CO3)2 · H 2O with at least 87\% yield could be formed and were also accompanied by some rectangular particles. High-resolution synchrotron powder X-ray diffraction provides crystal structure information, such as cell dimensions, and indexes the exact crystal packing with hexagonal symmetry, which is absent from the Joint Committee on Powder Diffraction Standards file, for the crystalline rhombus sample. Particle formation was studied based on the reaction time and the concentration ratio of [urea]/ [GdCl3 · 6H2O). After a calcination process, the amorphous spheres and crystalline rhombus Gd2O(CO3)2 · H2O particles convert in to crystalline Gd2O3 at temperatures above 600°C. For in vitro magnetic resonance imaging (MRI), both Gd 2O(CO3)2 · H2O and Gd 2O3 species show the promising T1- and T 2-weighted effects and could potentially serve as bimodal T 1-positive and T2-negative contrast agents. The amorphous Gd2O(CO3)2 · H2O contrast agent further demonstrates enhanced contrast of the liver and kidney using a dynamic contrast-enhanced MR imaging (DCE-MRI) technique for in vivo investigation. The multifunctional capability of he amorphous Gd 2O(CO3)2 · H2O spheres was also evidenced by the formation of nanoshells using these amorphous spheres as the template. Surface engineering of the amorphous Gd2O(CO 3)2 · H2O spheres could be performed by covalent bonding to form hollow silica nanoshells and hollow silica@Fe 3O4 hybrid particles.",

author = "Li, \{I. Fang\} and Su, \{Chia Hao\} and Sheu, \{Hwo Shuenn\} and Chiu, \{Hui Chi\} and Lo, \{Yi Wei\} and Lin, \{Wei Ting\} and Chen, \{Jyh Horng\} and Yeh, \{Chen Sheng\}",

year = "2008",

month = mar,

day = "11",

doi = "10.1002/adfm.200700702",

language = "英语",

volume = "18",

pages = "766--776",

journal = "Advanced Functional Materials",

issn = "1616-301X",

publisher = "John Wiley and Sons Inc",

number = "5",

}

Gd₂O(CO₃)₂ · H₂O particles and the corresponding Gd₂O₃: Synthesis and applications of magnetic resonance contrast agents and template particles for hollow spheres and hybrid composites. / Li, I. Fang; Su, Chia Hao; Sheu, Hwo Shuenn et al.
In: Advanced Functional Materials, Vol. 18, No. 5, 11.03.2008, p. 766-776.

Research output: Contribution to journal › Journal Article › peer-review

TY - JOUR

T1 - Gd2O(CO3)2 · H2O particles and the corresponding Gd2O3

T2 - Synthesis and applications of magnetic resonance contrast agents and template particles for hollow spheres and hybrid composites

AU - Li, I. Fang

AU - Su, Chia Hao

AU - Sheu, Hwo Shuenn

AU - Chiu, Hui Chi

AU - Lo, Yi Wei

AU - Lin, Wei Ting

AU - Chen, Jyh Horng

AU - Yeh, Chen Sheng

PY - 2008/3/11

Y1 - 2008/3/11

N2 - The solution approach was employed to yield multifunctional amorphous Gd2O(CO3)2 · H2O colloidal spheres by reflux of an aqueous solution containing GdCl3 · 6H2O and urea, By elongating the reaction time, crystalline rhombus-shaped Gd2O(CO3)2 · H 2O with at least 87% yield could be formed and were also accompanied by some rectangular particles. High-resolution synchrotron powder X-ray diffraction provides crystal structure information, such as cell dimensions, and indexes the exact crystal packing with hexagonal symmetry, which is absent from the Joint Committee on Powder Diffraction Standards file, for the crystalline rhombus sample. Particle formation was studied based on the reaction time and the concentration ratio of [urea]/ [GdCl3 · 6H2O). After a calcination process, the amorphous spheres and crystalline rhombus Gd2O(CO3)2 · H2O particles convert in to crystalline Gd2O3 at temperatures above 600°C. For in vitro magnetic resonance imaging (MRI), both Gd 2O(CO3)2 · H2O and Gd 2O3 species show the promising T1- and T 2-weighted effects and could potentially serve as bimodal T 1-positive and T2-negative contrast agents. The amorphous Gd2O(CO3)2 · H2O contrast agent further demonstrates enhanced contrast of the liver and kidney using a dynamic contrast-enhanced MR imaging (DCE-MRI) technique for in vivo investigation. The multifunctional capability of he amorphous Gd 2O(CO3)2 · H2O spheres was also evidenced by the formation of nanoshells using these amorphous spheres as the template. Surface engineering of the amorphous Gd2O(CO 3)2 · H2O spheres could be performed by covalent bonding to form hollow silica nanoshells and hollow silica@Fe 3O4 hybrid particles.

AB - The solution approach was employed to yield multifunctional amorphous Gd2O(CO3)2 · H2O colloidal spheres by reflux of an aqueous solution containing GdCl3 · 6H2O and urea, By elongating the reaction time, crystalline rhombus-shaped Gd2O(CO3)2 · H 2O with at least 87% yield could be formed and were also accompanied by some rectangular particles. High-resolution synchrotron powder X-ray diffraction provides crystal structure information, such as cell dimensions, and indexes the exact crystal packing with hexagonal symmetry, which is absent from the Joint Committee on Powder Diffraction Standards file, for the crystalline rhombus sample. Particle formation was studied based on the reaction time and the concentration ratio of [urea]/ [GdCl3 · 6H2O). After a calcination process, the amorphous spheres and crystalline rhombus Gd2O(CO3)2 · H2O particles convert in to crystalline Gd2O3 at temperatures above 600°C. For in vitro magnetic resonance imaging (MRI), both Gd 2O(CO3)2 · H2O and Gd 2O3 species show the promising T1- and T 2-weighted effects and could potentially serve as bimodal T 1-positive and T2-negative contrast agents. The amorphous Gd2O(CO3)2 · H2O contrast agent further demonstrates enhanced contrast of the liver and kidney using a dynamic contrast-enhanced MR imaging (DCE-MRI) technique for in vivo investigation. The multifunctional capability of he amorphous Gd 2O(CO3)2 · H2O spheres was also evidenced by the formation of nanoshells using these amorphous spheres as the template. Surface engineering of the amorphous Gd2O(CO 3)2 · H2O spheres could be performed by covalent bonding to form hollow silica nanoshells and hollow silica@Fe 3O4 hybrid particles.

UR - https://www.scopus.com/pages/publications/41149176127

U2 - 10.1002/adfm.200700702

DO - 10.1002/adfm.200700702

M3 - 文章

AN - SCOPUS:41149176127

SN - 1616-301X

VL - 18

SP - 766

EP - 776

JO - Advanced Functional Materials

JF - Advanced Functional Materials

IS - 5

ER -

Gd₂O(CO₃)₂ · H₂O particles and the corresponding Gd₂O₃: Synthesis and applications of magnetic resonance contrast agents and template particles for hollow spheres and hybrid composites

Abstract

Access to Document

Other files and links

Fingerprint

Cite this