Gelatin-functionalized mesoporous silica nanoparticles with sustained release properties for intracameral pharmacotherapy of glaucoma

Yu Te Liao; Chih Hung Lee; Si Tan Chen; Jui Yang Lai; Kevin C.W. Wu

doi:10.1039/c7tb01217a

Gelatin-functionalized mesoporous silica nanoparticles with sustained release properties for intracameral pharmacotherapy of glaucoma

Yu Te Liao
, Chih Hung Lee
, Si Tan Chen
, Jui Yang Lai^*
, Kevin C.W. Wu

^*Corresponding author for this work

National Taiwan University
Chang Gung University
National Health Research Institutes Taiwan

Research output: Contribution to journal › Journal Article › peer-review

73 Scopus citations

Abstract

Herein, pilocarpine-loaded gelatin-covered mesoporous silica nanoparticles (denoted as p/GM) were intracamerally administrated into the anterior chamber for the reduction of intraocular pressure (IOP). The in vitro release profile shows that p/GM demostrates a high release percentage (50%) with a long-lasting release profile (36 days). The in vivo studies showed the maintenance of IOP in eye with ocular hypertension for 21 days.

Original language	English
Pages (from-to)	7008-7013
Number of pages	6
Journal	Journal of Materials Chemistry B
Volume	5
Issue number	34
DOIs	https://doi.org/10.1039/c7tb01217a
State	Published - 2017

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Publisher Copyright:
© 2017 The Royal Society of Chemistry.

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abstract = "Herein, pilocarpine-loaded gelatin-covered mesoporous silica nanoparticles (denoted as p/GM) were intracamerally administrated into the anterior chamber for the reduction of intraocular pressure (IOP). The in vitro release profile shows that p/GM demostrates a high release percentage (50\%) with a long-lasting release profile (36 days). The in vivo studies showed the maintenance of IOP in eye with ocular hypertension for 21 days.",

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AU - Lee, Chih Hung

AU - Chen, Si Tan

AU - Lai, Jui Yang

AU - Wu, Kevin C.W.

PY - 2017

Y1 - 2017

N2 - Herein, pilocarpine-loaded gelatin-covered mesoporous silica nanoparticles (denoted as p/GM) were intracamerally administrated into the anterior chamber for the reduction of intraocular pressure (IOP). The in vitro release profile shows that p/GM demostrates a high release percentage (50%) with a long-lasting release profile (36 days). The in vivo studies showed the maintenance of IOP in eye with ocular hypertension for 21 days.

AB - Herein, pilocarpine-loaded gelatin-covered mesoporous silica nanoparticles (denoted as p/GM) were intracamerally administrated into the anterior chamber for the reduction of intraocular pressure (IOP). The in vitro release profile shows that p/GM demostrates a high release percentage (50%) with a long-lasting release profile (36 days). The in vivo studies showed the maintenance of IOP in eye with ocular hypertension for 21 days.

UR - https://www.scopus.com/pages/publications/85028612970

U2 - 10.1039/c7tb01217a

DO - 10.1039/c7tb01217a

M3 - 文章

C2 - 32263891

AN - SCOPUS:85028612970

SN - 2050-7518

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JO - Journal of Materials Chemistry B

JF - Journal of Materials Chemistry B

IS - 34

ER -

Gelatin-functionalized mesoporous silica nanoparticles with sustained release properties for intracameral pharmacotherapy of glaucoma

Abstract

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