TY - JOUR
T1 - Genetic and environmental risk factors for chronic kidney disease
AU - Obrador, Gregorio T.
AU - Schultheiss, Ulla T.
AU - Kretzler, Matthias
AU - Langham, Robyn G.
AU - Nangaku, Masaomi
AU - Pecoits-Filho, Roberto
AU - Pollock, Carol
AU - Rossert, Jerome
AU - Correa-Rotter, Ricardo
AU - Stenvinkel, Peter
AU - Walker, Robert
AU - Yang, Chih Wei
AU - Fox, Caroline S.
AU - Köttgen, Anna
N1 - Publisher Copyright:
© 2017 International Society of Nephrology
PY - 2017/10
Y1 - 2017/10
N2 - In order to change the current state of chronic kidney disease knowledge and therapeutics, a fundamental improvement in the understanding of genetic and environmental causes of chronic kidney disease is essential. This article first provides an overview of the existing knowledge gaps in our understanding of the genetic and environmental causes of chronic kidney disease, as well as their interactions. The second part of the article formulates goals that should be achieved in order to close these gaps, along with suggested timelines and stakeholders that are to be involved. A better understanding of genetic and environmental factors and their interactions that influence kidney function in healthy and diseased conditions can provide novel insights into renal physiology and pathophysiology and result in the identification of novel therapeutic or preventive targets to tackle the global public health care problem of chronic kidney disease.
AB - In order to change the current state of chronic kidney disease knowledge and therapeutics, a fundamental improvement in the understanding of genetic and environmental causes of chronic kidney disease is essential. This article first provides an overview of the existing knowledge gaps in our understanding of the genetic and environmental causes of chronic kidney disease, as well as their interactions. The second part of the article formulates goals that should be achieved in order to close these gaps, along with suggested timelines and stakeholders that are to be involved. A better understanding of genetic and environmental factors and their interactions that influence kidney function in healthy and diseased conditions can provide novel insights into renal physiology and pathophysiology and result in the identification of novel therapeutic or preventive targets to tackle the global public health care problem of chronic kidney disease.
KW - chronic kidney disease
KW - environment
KW - genetic kidney disease
KW - genetics
KW - genome-wide association studies
UR - http://www.scopus.com/inward/record.url?scp=85031720902&partnerID=8YFLogxK
U2 - 10.1016/j.kisu.2017.07.004
DO - 10.1016/j.kisu.2017.07.004
M3 - 文献综述
AN - SCOPUS:85031720902
SN - 2157-1724
VL - 7
SP - 88
EP - 106
JO - Kidney International Supplements
JF - Kidney International Supplements
IS - 2
ER -
