Genetic determinants of circulating galectin-3 levels in patients with coronary artery disease

Yu Huang Liao; Ming Sheng Teng; Jyh Ming J. Juang; Fu Tien Chiang; Leay Kiaw Er; Semon Wu; Yu Lin Ko

doi:10.1002/mgg3.1370

Genetic determinants of circulating galectin-3 levels in patients with coronary artery disease

Yu Huang Liao
, Ming Sheng Teng
, Jyh Ming J. Juang
, Fu Tien Chiang
, Leay Kiaw Er
, Semon Wu
, Yu Lin Ko^*

^*Corresponding author for this work

Research output: Contribution to journal › Journal Article › peer-review

6 Scopus citations

Abstract

Background: Galectin-3 plays a crucial role in the regulation of inflammation. The aim of this study was to elucidate the association between LGALS3 genotypes, galectin-3 levels, and inflammatory marker levels in patients with coronary artery disease (CAD). Results: A total of 474 patients with CAD were enrolled. Significant correlations were discerned between galectin-3 levels and leukocyte counts, C-reactive protein, soluble intercellular adhesion molecule-1, and matrix metalloproteinase 9 levels (all p <.05). The LGALS3 rs2274273, rs4644, rs4652 genotypes, and haplotypes CAC, CCC, and ACT exhibited a significant association with galectin-3 levels (for genotypes, p = 1.05 × 10⁻²⁵, 3.54 × 10⁻²⁵, and 2.74 × 10⁻⁷, respectively). Multivariate analysis showed LGALS3 rs2274273 and rs4644 genotypes contributing to 20.8% variation of galectin-3 levels. However, there was no association between LGALS3 genotypes and other inflammatory marker levels. Conclusions: Our data showed strong genetic determinants of galectin-3 levels in patients with CAD. The galectin-3 levels, but not LGALS3 genotypes, were associated with multiple inflammatory marker levels. Further study may be necessary to elucidate the molecular mechanism of galectin-3 in the pathogenesis of chronic inflammatory disorders.

Original language	English
Article number	e1370
Journal	Molecular Genetics and Genomic Medicine
Volume	8
Issue number	9
DOIs	https://doi.org/10.1002/mgg3.1370
State	Published - 01 09 2020
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2020 The Authors. Molecular Genetics & Genomic Medicine published by Wiley Periodicals LLC.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

CAD
Galectin-3
LGALS3 SNP

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10.1002/mgg3.1370

Cite this

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title = "Genetic determinants of circulating galectin-3 levels in patients with coronary artery disease",

abstract = "Background: Galectin-3 plays a crucial role in the regulation of inflammation. The aim of this study was to elucidate the association between LGALS3 genotypes, galectin-3 levels, and inflammatory marker levels in patients with coronary artery disease (CAD). Results: A total of 474 patients with CAD were enrolled. Significant correlations were discerned between galectin-3 levels and leukocyte counts, C-reactive protein, soluble intercellular adhesion molecule-1, and matrix metalloproteinase 9 levels (all p <.05). The LGALS3 rs2274273, rs4644, rs4652 genotypes, and haplotypes CAC, CCC, and ACT exhibited a significant association with galectin-3 levels (for genotypes, p = 1.05 × 10−25, 3.54 × 10−25, and 2.74 × 10−7, respectively). Multivariate analysis showed LGALS3 rs2274273 and rs4644 genotypes contributing to 20.8\% variation of galectin-3 levels. However, there was no association between LGALS3 genotypes and other inflammatory marker levels. Conclusions: Our data showed strong genetic determinants of galectin-3 levels in patients with CAD. The galectin-3 levels, but not LGALS3 genotypes, were associated with multiple inflammatory marker levels. Further study may be necessary to elucidate the molecular mechanism of galectin-3 in the pathogenesis of chronic inflammatory disorders.",

keywords = "CAD, Galectin-3, LGALS3 SNP",

author = "Liao, \{Yu Huang\} and Teng, \{Ming Sheng\} and Juang, \{Jyh Ming J.\} and Chiang, \{Fu Tien\} and Er, \{Leay Kiaw\} and Semon Wu and Ko, \{Yu Lin\}",

note = "Publisher Copyright: {\textcopyright} 2020 The Authors. Molecular Genetics \& Genomic Medicine published by Wiley Periodicals LLC.",

year = "2020",

month = sep,

day = "1",

doi = "10.1002/mgg3.1370",

language = "英语",

volume = "8",

journal = "Molecular Genetics and Genomic Medicine",

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number = "9",

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TY - JOUR

T1 - Genetic determinants of circulating galectin-3 levels in patients with coronary artery disease

AU - Liao, Yu Huang

AU - Teng, Ming Sheng

AU - Juang, Jyh Ming J.

AU - Chiang, Fu Tien

AU - Er, Leay Kiaw

AU - Wu, Semon

AU - Ko, Yu Lin

PY - 2020/9/1

Y1 - 2020/9/1

N2 - Background: Galectin-3 plays a crucial role in the regulation of inflammation. The aim of this study was to elucidate the association between LGALS3 genotypes, galectin-3 levels, and inflammatory marker levels in patients with coronary artery disease (CAD). Results: A total of 474 patients with CAD were enrolled. Significant correlations were discerned between galectin-3 levels and leukocyte counts, C-reactive protein, soluble intercellular adhesion molecule-1, and matrix metalloproteinase 9 levels (all p <.05). The LGALS3 rs2274273, rs4644, rs4652 genotypes, and haplotypes CAC, CCC, and ACT exhibited a significant association with galectin-3 levels (for genotypes, p = 1.05 × 10−25, 3.54 × 10−25, and 2.74 × 10−7, respectively). Multivariate analysis showed LGALS3 rs2274273 and rs4644 genotypes contributing to 20.8% variation of galectin-3 levels. However, there was no association between LGALS3 genotypes and other inflammatory marker levels. Conclusions: Our data showed strong genetic determinants of galectin-3 levels in patients with CAD. The galectin-3 levels, but not LGALS3 genotypes, were associated with multiple inflammatory marker levels. Further study may be necessary to elucidate the molecular mechanism of galectin-3 in the pathogenesis of chronic inflammatory disorders.

AB - Background: Galectin-3 plays a crucial role in the regulation of inflammation. The aim of this study was to elucidate the association between LGALS3 genotypes, galectin-3 levels, and inflammatory marker levels in patients with coronary artery disease (CAD). Results: A total of 474 patients with CAD were enrolled. Significant correlations were discerned between galectin-3 levels and leukocyte counts, C-reactive protein, soluble intercellular adhesion molecule-1, and matrix metalloproteinase 9 levels (all p <.05). The LGALS3 rs2274273, rs4644, rs4652 genotypes, and haplotypes CAC, CCC, and ACT exhibited a significant association with galectin-3 levels (for genotypes, p = 1.05 × 10−25, 3.54 × 10−25, and 2.74 × 10−7, respectively). Multivariate analysis showed LGALS3 rs2274273 and rs4644 genotypes contributing to 20.8% variation of galectin-3 levels. However, there was no association between LGALS3 genotypes and other inflammatory marker levels. Conclusions: Our data showed strong genetic determinants of galectin-3 levels in patients with CAD. The galectin-3 levels, but not LGALS3 genotypes, were associated with multiple inflammatory marker levels. Further study may be necessary to elucidate the molecular mechanism of galectin-3 in the pathogenesis of chronic inflammatory disorders.

KW - CAD

KW - Galectin-3

KW - LGALS3 SNP

UR - https://www.scopus.com/pages/publications/85087304677

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DO - 10.1002/mgg3.1370

M3 - 文章

C2 - 32573962

AN - SCOPUS:85087304677

SN - 2324-9269

VL - 8

JO - Molecular Genetics and Genomic Medicine

JF - Molecular Genetics and Genomic Medicine

IS - 9

M1 - e1370

ER -

Genetic determinants of circulating galectin-3 levels in patients with coronary artery disease

Abstract

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Keywords

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