Genetic Variations of GAK in Two Chinese Parkinson's Disease Populations: A Case-Control Study

Wei En Johnny Tseng; Chiung Mei Chen; Yi Chun Chen; Zhao Yi; Eng King Tan; Yih Ru Wu

doi:10.1371/journal.pone.0067506

Genetic Variations of GAK in Two Chinese Parkinson's Disease Populations: A Case-Control Study

Wei En Johnny Tseng, Chiung Mei Chen, Yi Chun Chen, Zhao Yi, Eng King Tan, Yih Ru Wu^*

^*Corresponding author for this work

School of Medicine

Research output: Contribution to journal › Journal Article › peer-review

16 Scopus citations

Abstract

Cyclin G-associated kinase (GAK) modifies α-synuclein expression levels and affects the susceptibility of Parkinson's disease (PD). The single-nucleotide polymorphism (SNP) rs1564282 of GAK gene has a significant association to the risk of PD among Caucasian populations. To date there is only one data with regards to ethnic Chinese from Mainland China. Here, we conducted a case-control study in two independent cohorts of Han Chinese populations from Taiwan and Singapore to validate this association. A total of 1,755 subjects (871 PD patients and 884 controls) were recruited. The results showed that neither the CT, TT genotypes nor the minor allele T of SNP rs1564282 were associated with PD among the subjects from Taiwan and Singapore as well as in the pooled analysis. Differences in our study population with regards to published literature may be due to epigenetic factors and gene-gene or gene-environmental interactions. Further studies in other Chinese populations will be of interest to validate these findings.

Original language	English
Article number	e67506
Journal	PLoS ONE
Volume	8
Issue number	6
DOIs	https://doi.org/10.1371/journal.pone.0067506
State	Published - 24 06 2013

Access to Document

10.1371/journal.pone.0067506

Cite this

@article{532c61f96ba74597a56d84d50721c83a,

title = "Genetic Variations of GAK in Two Chinese Parkinson's Disease Populations: A Case-Control Study",

abstract = "Cyclin G-associated kinase (GAK) modifies α-synuclein expression levels and affects the susceptibility of Parkinson's disease (PD). The single-nucleotide polymorphism (SNP) rs1564282 of GAK gene has a significant association to the risk of PD among Caucasian populations. To date there is only one data with regards to ethnic Chinese from Mainland China. Here, we conducted a case-control study in two independent cohorts of Han Chinese populations from Taiwan and Singapore to validate this association. A total of 1,755 subjects (871 PD patients and 884 controls) were recruited. The results showed that neither the CT, TT genotypes nor the minor allele T of SNP rs1564282 were associated with PD among the subjects from Taiwan and Singapore as well as in the pooled analysis. Differences in our study population with regards to published literature may be due to epigenetic factors and gene-gene or gene-environmental interactions. Further studies in other Chinese populations will be of interest to validate these findings.",

author = "Tseng, {Wei En Johnny} and Chen, {Chiung Mei} and Chen, {Yi Chun} and Zhao Yi and Tan, {Eng King} and Wu, {Yih Ru}",

year = "2013",

month = jun,

day = "24",

doi = "10.1371/journal.pone.0067506",

language = "英语",

volume = "8",

journal = "PLoS ONE",

issn = "1932-6203",

number = "6",

}

TY - JOUR

T1 - Genetic Variations of GAK in Two Chinese Parkinson's Disease Populations

T2 - A Case-Control Study

AU - Tseng, Wei En Johnny

AU - Chen, Chiung Mei

AU - Chen, Yi Chun

AU - Yi, Zhao

AU - Tan, Eng King

AU - Wu, Yih Ru

PY - 2013/6/24

Y1 - 2013/6/24

N2 - Cyclin G-associated kinase (GAK) modifies α-synuclein expression levels and affects the susceptibility of Parkinson's disease (PD). The single-nucleotide polymorphism (SNP) rs1564282 of GAK gene has a significant association to the risk of PD among Caucasian populations. To date there is only one data with regards to ethnic Chinese from Mainland China. Here, we conducted a case-control study in two independent cohorts of Han Chinese populations from Taiwan and Singapore to validate this association. A total of 1,755 subjects (871 PD patients and 884 controls) were recruited. The results showed that neither the CT, TT genotypes nor the minor allele T of SNP rs1564282 were associated with PD among the subjects from Taiwan and Singapore as well as in the pooled analysis. Differences in our study population with regards to published literature may be due to epigenetic factors and gene-gene or gene-environmental interactions. Further studies in other Chinese populations will be of interest to validate these findings.

AB - Cyclin G-associated kinase (GAK) modifies α-synuclein expression levels and affects the susceptibility of Parkinson's disease (PD). The single-nucleotide polymorphism (SNP) rs1564282 of GAK gene has a significant association to the risk of PD among Caucasian populations. To date there is only one data with regards to ethnic Chinese from Mainland China. Here, we conducted a case-control study in two independent cohorts of Han Chinese populations from Taiwan and Singapore to validate this association. A total of 1,755 subjects (871 PD patients and 884 controls) were recruited. The results showed that neither the CT, TT genotypes nor the minor allele T of SNP rs1564282 were associated with PD among the subjects from Taiwan and Singapore as well as in the pooled analysis. Differences in our study population with regards to published literature may be due to epigenetic factors and gene-gene or gene-environmental interactions. Further studies in other Chinese populations will be of interest to validate these findings.

UR - http://www.scopus.com/inward/record.url?scp=84879489900&partnerID=8YFLogxK

U2 - 10.1371/journal.pone.0067506

DO - 10.1371/journal.pone.0067506

M3 - 文章

C2 - 23826309

AN - SCOPUS:84879489900

SN - 1932-6203

VL - 8

JO - PLoS ONE

JF - PLoS ONE

IS - 6

M1 - e67506

ER -

Genetic Variations of GAK in Two Chinese Parkinson's Disease Populations: A Case-Control Study

Abstract

Access to Document

Other files and links

Fingerprint

Cite this